PMID- 20385361
OWN - NLM
STAT- MEDLINE
DCOM- 20100430
LR  - 20230131
IS  - 1878-3686 (Electronic)
IS  - 1535-6108 (Linking)
VI  - 17
IP  - 4
DP  - 2010 Apr 13
TI  - A hierarchy of self-renewing tumor-initiating cell types in glioblastoma.
PG  - 362-75
LID - 10.1016/j.ccr.2009.12.049 [doi]
AB  - The neural stem cell marker CD133 is reported to identify cells within 
      glioblastoma (GBM) that can initiate neurosphere growth and tumor formation; 
      however, instances of CD133(-) cells exhibiting similar properties have also been 
      reported. Here, we show that some PTEN-deficient GBM tumors produce a series of 
      CD133(+) and CD133(-) self-renewing tumor-initiating cell types and provide 
      evidence that these cell types constitute a lineage hierarchy. Our results show 
      that the capacities for self-renewal and tumor initiation in GBM need not be 
      restricted to a uniform population of stemlike cells, but can be shared by a 
      lineage of self-renewing cell types expressing a range of markers of forebrain 
      lineage.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Chen, Ruihuan
AU  - Chen R
AD  - Department of Tumor Biology and Angiogenesis, Genentech Inc., San Francisco, CA 
      94080, USA.
FAU - Nishimura, Merry C
AU  - Nishimura MC
FAU - Bumbaca, Stephanie M
AU  - Bumbaca SM
FAU - Kharbanda, Samir
AU  - Kharbanda S
FAU - Forrest, William F
AU  - Forrest WF
FAU - Kasman, Ian M
AU  - Kasman IM
FAU - Greve, Joan M
AU  - Greve JM
FAU - Soriano, Robert H
AU  - Soriano RH
FAU - Gilmour, Laurie L
AU  - Gilmour LL
FAU - Rivers, Celina Sanchez
AU  - Rivers CS
FAU - Modrusan, Zora
AU  - Modrusan Z
FAU - Nacu, Serban
AU  - Nacu S
FAU - Guerrero, Steve
AU  - Guerrero S
FAU - Edgar, Kyle A
AU  - Edgar KA
FAU - Wallin, Jeffrey J
AU  - Wallin JJ
FAU - Lamszus, Katrin
AU  - Lamszus K
FAU - Westphal, Manfred
AU  - Westphal M
FAU - Heim, Susanne
AU  - Heim S
FAU - James, C David
AU  - James CD
FAU - VandenBerg, Scott R
AU  - VandenBerg SR
FAU - Costello, Joseph F
AU  - Costello JF
FAU - Moorefield, Scott
AU  - Moorefield S
FAU - Cowdrey, Cynthia J
AU  - Cowdrey CJ
FAU - Prados, Michael
AU  - Prados M
FAU - Phillips, Heidi S
AU  - Phillips HS
LA  - eng
SI  - GEO/GSE19612
GR  - P50 CA097257/CA/NCI NIH HHS/United States
GR  - CA 097257/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Cell
JT  - Cancer cell
JID - 101130617
RN  - 0 (AC133 Antigen)
RN  - 0 (Antigens, CD)
RN  - 0 (Glycoproteins)
RN  - 0 (PROM1 protein, human)
RN  - 0 (Peptides)
SB  - IM
MH  - AC133 Antigen
MH  - Antigens, CD/analysis/genetics
MH  - Brain Neoplasms/genetics/*pathology
MH  - Cell Differentiation
MH  - Cell Division
MH  - Cellular Structures/*pathology
MH  - Flow Cytometry
MH  - Gene Expression Profiling
MH  - Genetic Linkage
MH  - Glioblastoma/genetics/*pathology
MH  - Glycoproteins/analysis/deficiency/genetics
MH  - Humans
MH  - Immunohistochemistry
MH  - Kinetics
MH  - Neoplastic Stem Cells/pathology/transplantation
MH  - Peptides/analysis/deficiency/genetics
EDAT- 2010/04/14 06:00
MHDA- 2010/05/01 06:00
CRDT- 2010/04/14 06:00
PHST- 2009/04/14 00:00 [received]
PHST- 2009/09/30 00:00 [revised]
PHST- 2010/02/08 00:00 [accepted]
PHST- 2010/04/14 06:00 [entrez]
PHST- 2010/04/14 06:00 [pubmed]
PHST- 2010/05/01 06:00 [medline]
AID - S1535-6108(10)00065-6 [pii]
AID - 10.1016/j.ccr.2009.12.049 [doi]
PST - ppublish
SO  - Cancer Cell. 2010 Apr 13;17(4):362-75. doi: 10.1016/j.ccr.2009.12.049.