PMID- 20388652
OWN - NLM
STAT- MEDLINE
DCOM- 20100421
LR  - 20211020
IS  - 1477-9129 (Electronic)
IS  - 0950-1991 (Print)
IS  - 0950-1991 (Linking)
VI  - 137
IP  - 9
DP  - 2010 May
TI  - Mechanical control of tissue and organ development.
PG  - 1407-20
LID - 10.1242/dev.024166 [doi]
AB  - Many genes and molecules that drive tissue patterning during organogenesis and 
      tissue regeneration have been discovered. Yet, we still lack a full understanding 
      of how these chemical cues induce the formation of living tissues with their 
      unique shapes and material properties. Here, we review work based on the 
      convergence of physics, engineering and biology that suggests that mechanical 
      forces generated by living cells are as crucial as genes and chemical signals for 
      the control of embryological development, morphogenesis and tissue patterning.
FAU - Mammoto, Tadanori
AU  - Mammoto T
AD  - Vascular Biology Program, Children's Hospital and Harvard Medical School, Boston, 
      MA 02115, USA.
FAU - Ingber, Donald E
AU  - Ingber DE
LA  - eng
GR  - RL1 DE019021/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
SB  - IM
MH  - Animals
MH  - Biomechanical Phenomena/*physiology
MH  - Embryonic Development/physiology
MH  - Humans
MH  - Models, Biological
MH  - Morphogenesis/*physiology
MH  - Organogenesis/physiology
MH  - Signal Transduction/*physiology
PMC - PMC2853843
EDAT- 2010/04/15 06:00
MHDA- 2010/04/22 06:00
PMCR- 2011/05/01
CRDT- 2010/04/15 06:00
PHST- 2010/04/15 06:00 [entrez]
PHST- 2010/04/15 06:00 [pubmed]
PHST- 2010/04/22 06:00 [medline]
PHST- 2011/05/01 00:00 [pmc-release]
AID - 137/9/1407 [pii]
AID - 10.1242/dev.024166 [doi]
PST - ppublish
SO  - Development. 2010 May;137(9):1407-20. doi: 10.1242/dev.024166.