PMID- 20399149
OWN - NLM
STAT- MEDLINE
DCOM- 20100601
LR  - 20230131
IS  - 1878-3686 (Electronic)
IS  - 1535-6108 (Print)
IS  - 1535-6108 (Linking)
VI  - 17
IP  - 5
DP  - 2010 May 18
TI  - Identification of a CpG island methylator phenotype that defines a distinct 
      subgroup of glioma.
PG  - 510-22
LID - 10.1016/j.ccr.2010.03.017 [doi]
AB  - We have profiled promoter DNA methylation alterations in 272 glioblastoma tumors 
      in the context of The Cancer Genome Atlas (TCGA). We found that a distinct subset 
      of samples displays concerted hypermethylation at a large number of loci, 
      indicating the existence of a glioma-CpG island methylator phenotype (G-CIMP). We 
      validated G-CIMP in a set of non-TCGA glioblastomas and low-grade gliomas. G-CIMP 
      tumors belong to the proneural subgroup, are more prevalent among lower-grade 
      gliomas, display distinct copy-number alterations, and are tightly associated 
      with IDH1 somatic mutations. Patients with G-CIMP tumors are younger at the time 
      of diagnosis and experience significantly improved outcome. These findings 
      identify G-CIMP as a distinct subset of human gliomas on molecular and clinical 
      grounds.
CI  - (c) 2010 Elsevier Inc. All rights reserved.
FAU - Noushmehr, Houtan
AU  - Noushmehr H
AD  - USC Epigenome Center, University of Southern California, Los Angeles, CA 90033, 
      USA.
FAU - Weisenberger, Daniel J
AU  - Weisenberger DJ
FAU - Diefes, Kristin
AU  - Diefes K
FAU - Phillips, Heidi S
AU  - Phillips HS
FAU - Pujara, Kanan
AU  - Pujara K
FAU - Berman, Benjamin P
AU  - Berman BP
FAU - Pan, Fei
AU  - Pan F
FAU - Pelloski, Christopher E
AU  - Pelloski CE
FAU - Sulman, Erik P
AU  - Sulman EP
FAU - Bhat, Krishna P
AU  - Bhat KP
FAU - Verhaak, Roel G W
AU  - Verhaak RG
FAU - Hoadley, Katherine A
AU  - Hoadley KA
FAU - Hayes, D Neil
AU  - Hayes DN
FAU - Perou, Charles M
AU  - Perou CM
FAU - Schmidt, Heather K
AU  - Schmidt HK
FAU - Ding, Li
AU  - Ding L
FAU - Wilson, Richard K
AU  - Wilson RK
FAU - Van Den Berg, David
AU  - Van Den Berg D
FAU - Shen, Hui
AU  - Shen H
FAU - Bengtsson, Henrik
AU  - Bengtsson H
FAU - Neuvial, Pierre
AU  - Neuvial P
FAU - Cope, Leslie M
AU  - Cope LM
FAU - Buckley, Jonathan
AU  - Buckley J
FAU - Herman, James G
AU  - Herman JG
FAU - Baylin, Stephen B
AU  - Baylin SB
FAU - Laird, Peter W
AU  - Laird PW
FAU - Aldape, Kenneth
AU  - Aldape K
CN  - Cancer Genome Atlas Research Network
LA  - eng
GR  - U24 CA126561-03/CA/NCI NIH HHS/United States
GR  - U24 CA143882/CA/NCI NIH HHS/United States
GR  - U24 CA143882-01/CA/NCI NIH HHS/United States
GR  - P50CA127001/CA/NCI NIH HHS/United States
GR  - U24 CA126561/CA/NCI NIH HHS/United States
GR  - P50 CA127001/CA/NCI NIH HHS/United States
GR  - U24 CA143848/CA/NCI NIH HHS/United States
GR  - U24 CA126561-03S1/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100415
PL  - United States
TA  - Cancer Cell
JT  - Cancer cell
JID - 101130617
RN  - EC 1.1.1.41 (Isocitrate Dehydrogenase)
RN  - EC 1.1.1.42. (IDH1 protein, human)
SB  - IM
CIN - Cancer Cell. 2010 May 18;17(5):419-20. PMID: 20478523
MH  - Brain Neoplasms/*genetics/pathology
MH  - *CpG Islands
MH  - *DNA Methylation
MH  - Glioblastoma/*genetics/pathology
MH  - Humans
MH  - Isocitrate Dehydrogenase/genetics
MH  - Mutation
MH  - Phenotype
PMC - PMC2872684
MID - NIHMS198493
COIS- Conflict of interest statement P.W.L. is a shareholder, consultant and scientific 
      advisory board member of Epigenomics, AG, which has a commercial interest in DNA 
      methylation markers. This work was not supported by Epigenomics, AG. K.A. is a 
      consultant and scientific advisory board member for Castle Biosciences, which has 
      a commercial interest in molecular diagnostics. This work was not supported by 
      Castle Biosciences.
EDAT- 2010/04/20 06:00
MHDA- 2010/06/02 06:00
PMCR- 2011/05/18
CRDT- 2010/04/20 06:00
PHST- 2009/12/08 00:00 [received]
PHST- 2010/02/18 00:00 [revised]
PHST- 2010/03/30 00:00 [accepted]
PHST- 2010/04/20 06:00 [entrez]
PHST- 2010/04/20 06:00 [pubmed]
PHST- 2010/06/02 06:00 [medline]
PHST- 2011/05/18 00:00 [pmc-release]
AID - S1535-6108(10)00108-X [pii]
AID - 10.1016/j.ccr.2010.03.017 [doi]
PST - ppublish
SO  - Cancer Cell. 2010 May 18;17(5):510-22. doi: 10.1016/j.ccr.2010.03.017. Epub 2010 
      Apr 15.