PMID- 20401880 OWN - NLM STAT- MEDLINE DCOM- 20100719 LR - 20231110 IS - 1521-3773 (Electronic) IS - 1433-7851 (Print) IS - 1433-7851 (Linking) VI - 49 IP - 19 DP - 2010 Apr 26 TI - Gold nanoparticles for biology and medicine. PG - 3280-94 LID - 10.1002/anie.200904359 [doi] AB - Gold colloids have fascinated scientists for over a century and are now heavily utilized in chemistry, biology, engineering, and medicine. Today these materials can be synthesized reproducibly, modified with seemingly limitless chemical functional groups, and, in certain cases, characterized with atomic-level precision. This Review highlights recent advances in the synthesis, bioconjugation, and cellular uses of gold nanoconjugates. There are now many examples of highly sensitive and selective assays based upon gold nanoconjugates. In recent years, focus has turned to therapeutic possibilities for such materials. Structures which behave as gene-regulating agents, drug carriers, imaging agents, and photoresponsive therapeutics have been developed and studied in the context of cells and many debilitating diseases. These structures are not simply chosen as alternatives to molecule-based systems, but rather for their new physical and chemical properties, which confer substantive advantages in cellular and medical applications. FAU - Giljohann, David A AU - Giljohann DA AD - Department of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113, USA. FAU - Seferos, Dwight S AU - Seferos DS FAU - Daniel, Weston L AU - Daniel WL FAU - Massich, Matthew D AU - Massich MD FAU - Patel, Pinal C AU - Patel PC FAU - Mirkin, Chad A AU - Mirkin CA LA - eng GR - DP1 OD000285/OD/NIH HHS/United States GR - U54 CA119341/CA/NCI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. PT - Review PL - Germany TA - Angew Chem Int Ed Engl JT - Angewandte Chemie (International ed. in English) JID - 0370543 RN - 0 (Contrast Media) RN - 0 (Drug Carriers) RN - 0 (Photosensitizing Agents) RN - 0 (RNA, Antisense) RN - 7440-57-5 (Gold) SB - IM MH - Animals MH - Contrast Media/chemistry MH - Drug Carriers/chemistry MH - Gene Transfer Techniques MH - Gold/*chemistry MH - Humans MH - Metal Nanoparticles/*chemistry MH - Photosensitizing Agents/chemistry MH - RNA, Antisense/metabolism PMC - PMC3930332 MID - NIHMS551624 EDAT- 2010/04/20 06:00 MHDA- 2010/07/20 06:00 PMCR- 2014/02/20 CRDT- 2010/04/20 06:00 PHST- 2010/04/20 06:00 [entrez] PHST- 2010/04/20 06:00 [pubmed] PHST- 2010/07/20 06:00 [medline] PHST- 2014/02/20 00:00 [pmc-release] AID - 10.1002/anie.200904359 [doi] PST - ppublish SO - Angew Chem Int Ed Engl. 2010 Apr 26;49(19):3280-94. doi: 10.1002/anie.200904359.