PMID- 20406446
OWN - NLM
STAT- MEDLINE
DCOM- 20100719
LR  - 20211020
IS  - 1745-6150 (Electronic)
IS  - 1745-6150 (Linking)
VI  - 5
DP  - 2010 Apr 20
TI  - A new stochastic and state space model of human colon cancer incorporating 
      multiple pathways.
PG  - 26
LID - 10.1186/1745-6150-5-26 [doi]
AB  - BACKGROUND AND PURPOSE: Studies by molecular biologists and geneticists have 
      shown that tumors of human colon cancer are developed from colon stem cells 
      through two mechanisms: The chromosomal instability and the micro-satellite 
      instability. The purpose of this paper is therefore to develop a new stochastic 
      and state space model for carcinogenesis of human colon cancer incorporating 
      these biological mechanisms. RESULTS: Based on recent biological studies, in this 
      paper we have developed a state space model for human colon cancer. In this state 
      space model, the stochastic system is represented by a stochastic model, 
      involving 2 different pathways-the chromosomal instability pathway and the 
      micro-satellite instability pathway; the observation, cancer incidence data, is 
      represented by a statistical model. Based on this model we have developed a 
      generalized Bayesian approach to estimate the parameters through the posterior 
      modes of the parameters via Gibbs sampling procedures. We have applied this model 
      to fit and analyze the SEER data of human colon cancers from NCI/NIH. 
      CONCLUSIONS: Our results indicate that the model not only provides a logical 
      avenue to incorporate biological information but also fits the data much better 
      than other models including the 4-stage single pathway model. This model not only 
      would provide more insights into human colon cancer but also would provide useful 
      guidance for its prevention and control and for prediction of future cancer 
      cases.
FAU - Tan, Wai Y
AU  - Tan WY
AD  - Department of Mathematical Sciences, The University of Memphis, Memphis, TN 
      38152-6429, USA. waitan@memphis.edu
FAU - Yan, Xiao W
AU  - Yan XW
LA  - eng
GR  - R15 CA113347-01/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20100420
PL  - England
TA  - Biol Direct
JT  - Biology direct
JID - 101258412
SB  - IM
MH  - Colonic Neoplasms/*metabolism
MH  - Humans
MH  - *Models, Statistical
MH  - Signal Transduction/*physiology
MH  - Stochastic Processes
PMC - PMC2875223
EDAT- 2010/04/22 06:00
MHDA- 2010/07/20 06:00
PMCR- 2010/04/20
CRDT- 2010/04/22 06:00
PHST- 2010/01/19 00:00 [received]
PHST- 2010/04/20 00:00 [accepted]
PHST- 2010/04/22 06:00 [entrez]
PHST- 2010/04/22 06:00 [pubmed]
PHST- 2010/07/20 06:00 [medline]
PHST- 2010/04/20 00:00 [pmc-release]
AID - 1745-6150-5-26 [pii]
AID - 10.1186/1745-6150-5-26 [doi]
PST - epublish
SO  - Biol Direct. 2010 Apr 20;5:26. doi: 10.1186/1745-6150-5-26.