PMID- 20413894
OWN - NLM
STAT- MEDLINE
DCOM- 20101012
LR  - 20131121
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 20
IP  - 4
DP  - 2010
TI  - PPARgamma agonist curcumin reduces the amyloid-beta-stimulated inflammatory 
      responses in primary astrocytes.
PG  - 1189-99
LID - 10.3233/JAD-2010-091336 [doi]
AB  - Alzheimer's disease (AD) is the most common age-related neurodegenerative 
      disorder. Accumulating data indicate that astrocytes play an important role in 
      the neuroinflammation related to the pathogenesis of AD. It has been shown that 
      microglia and astrocytes are activated in AD brain and amyloid-beta (Abeta) can 
      increase the expression of cyclooxygenase 2 (COX-2), interleukin-1, and 
      interleukin-6. Suppressing the inflammatory response caused by activated 
      astrocytes may help to inhibit the development of AD. Curcumin is a major 
      constituent of the yellow curry spice turmeric and proved to be a potential 
      anti-inflammatory drug in arthritis and colitis. There is a low age-adjusted 
      prevalence of AD in India, a country where turmeric powder is commonly used as a 
      culinary compound. Curcumin has been shown to suppress activated astroglia in 
      amyloid-beta protein precursor transgenic mice. The real mechanism by which 
      curcumin inhibits activated astroglia is poorly understood. Here we report that 
      the expression of COX-2 and glial fibrillary acidic protein were enhanced and 
      that of peroxisome proliferator-activated receptor gamma (PPARgamma) was 
      decreased in Abeta(25-35)-treated astrocytes. In line with these results, nuclear 
      factor-kappaB translocation was increased in the presence of Abeta. All these can 
      be reversed by the pretreatment of curcumin. Furthermore, GW9662, a PPARgamma 
      antagonist, can abolish the anti-inflammatory effect of curcumin. These results 
      show that curcumin might act as a PPARgamma agonist to inhibit the inflammation 
      in Abeta-treated astrocytes.
FAU - Wang, Hong-Mei
AU  - Wang HM
AD  - Department of Neurology & Institute of Neurology, Ruijin Hospital, Shanghai Jiao 
      Tong University School of Medicine, Shanghai, PR China.
FAU - Zhao, Yan-Xin
AU  - Zhao YX
FAU - Zhang, Shi
AU  - Zhang S
FAU - Liu, Gui-Dong
AU  - Liu GD
FAU - Kang, Wen-Yan
AU  - Kang WY
FAU - Tang, Hui-Dong
AU  - Tang HD
FAU - Ding, Jian-Qing
AU  - Ding JQ
FAU - Chen, Sheng-Di
AU  - Chen SD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
RN  - 0 (2-chloro-5-nitrobenzanilide)
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Anilides)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (PPAR gamma)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Amyloid beta-Peptides/*antagonists & inhibitors/*toxicity
MH  - Anilides/pharmacology
MH  - Animals
MH  - Animals, Newborn
MH  - Astrocytes/*pathology
MH  - Cells, Cultured
MH  - Curcumin/*pharmacology
MH  - Cyclooxygenase 2/genetics/metabolism
MH  - Glial Fibrillary Acidic Protein/genetics/metabolism
MH  - Inflammation/pathology
MH  - Nerve Tissue Proteins/metabolism
MH  - Nuclear Proteins/metabolism
MH  - PPAR gamma/*agonists
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2010/04/24 06:00
MHDA- 2010/10/13 06:00
CRDT- 2010/04/24 06:00
PHST- 2010/04/24 06:00 [entrez]
PHST- 2010/04/24 06:00 [pubmed]
PHST- 2010/10/13 06:00 [medline]
AID - N815505T27635721 [pii]
AID - 10.3233/JAD-2010-091336 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2010;20(4):1189-99. doi: 10.3233/JAD-2010-091336.