PMID- 20417962
OWN - NLM
STAT- MEDLINE
DCOM- 20100823
LR  - 20220330
IS  - 1878-5905 (Electronic)
IS  - 0142-9612 (Print)
IS  - 0142-9612 (Linking)
VI  - 31
IP  - 21
DP  - 2010 Jul
TI  - Surface charge-mediated rapid hepatobiliary excretion of mesoporous silica 
      nanoparticles.
PG  - 5564-74
LID - 10.1016/j.biomaterials.2010.03.048 [doi]
AB  - Nanoparticle-assisted drug delivery has been emerging as an active research area 
      in recent years. The in vivo biodistribution of nanoparticle and its following 
      mechanisms of biodegradation and/or excretion determine the feasibility and 
      applicability of such a nano-delivery platform in the practical clinical 
      translation. In this work we report the synthesis of the highly positive charge, 
      near-infrared fluorescent mesoporous silica nanoparticles (MSNs) that demonstrate 
      rapid hepatobiliary excretion, for use as traceable drug delivery platforms of 
      high capacity. MSNs were incorporated with near-infrared fluorescent dye 
      indocyanine green (ICG) via covalent or ionic bonding, to derive comparable 
      constructs of significantly different net surface charge. In vivo fluorescence 
      imaging and subsequent inductively coupled plasma-mass spectroscopy of harvested 
      tissues, urine, and feces revealed markedly different uptake and elimination 
      behaviors between the two conjugations; with more highly charged moieties (+34.4 
      mV at pH 7.4) being quickly excreted from the liver into the gastrointestinal 
      tract, while less charged moieties (-17.6 mV at pH 7.4) remained sequestered 
      within the liver. Taken together, these findings suggest that charge-dependent 
      adsorption of serum proteins greatly facilitates the hepatobiliary excretion of 
      silica nanoparticles, and that nanoparticle residence time in vivo can be 
      regulated by manipulation of surface charge.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Souris, Jeffrey S
AU  - Souris JS
AD  - Department of Radiology, The University of Chicago, Chicago, IL 60637, USA.
FAU - Lee, Chia-Hung
AU  - Lee CH
FAU - Cheng, Shih-Hsun
AU  - Cheng SH
FAU - Chen, Chin-Tu
AU  - Chen CT
FAU - Yang, Chung-Shi
AU  - Yang CS
FAU - Ho, Ja-an A
AU  - Ho JA
FAU - Mou, Chung-Yuan
AU  - Mou CY
FAU - Lo, Leu-Wei
AU  - Lo LW
LA  - eng
GR  - P30 CA014599-34/CA/NCI NIH HHS/United States
GR  - P30 CA014599/CA/NCI NIH HHS/United States
GR  - UL1 RR024999-03/RR/NCRR NIH HHS/United States
GR  - U54 RR023560/RR/NCRR NIH HHS/United States
GR  - UL1 RR024999/RR/NCRR NIH HHS/United States
GR  - P30 CA14599/CA/NCI NIH HHS/United States
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100424
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
RN  - 0 (Coloring Agents)
RN  - 0 (Drug Carriers)
RN  - 0 (Fluorescent Dyes)
RN  - 7631-86-9 (Silicon Dioxide)
RN  - IX6J1063HV (Indocyanine Green)
SB  - IM
MH  - Animals
MH  - Coloring Agents/chemistry/metabolism
MH  - Drug Carriers/chemistry/*metabolism
MH  - Drug Delivery Systems
MH  - Fluorescent Dyes/chemistry/metabolism
MH  - Indocyanine Green/chemistry/metabolism
MH  - Liver/*metabolism/ultrastructure
MH  - Male
MH  - Materials Testing
MH  - Mice
MH  - Mice, Nude
MH  - Molecular Structure
MH  - Nanoparticles/*chemistry
MH  - Silicon Dioxide/chemistry/*metabolism
MH  - Surface Properties
PMC - PMC2875342
MID - NIHMS194288
EDAT- 2010/04/27 06:00
MHDA- 2010/08/24 06:00
PMCR- 2011/07/01
CRDT- 2010/04/27 06:00
PHST- 2010/02/11 00:00 [received]
PHST- 2010/03/18 00:00 [accepted]
PHST- 2010/04/27 06:00 [entrez]
PHST- 2010/04/27 06:00 [pubmed]
PHST- 2010/08/24 06:00 [medline]
PHST- 2011/07/01 00:00 [pmc-release]
AID - S0142-9612(10)00419-9 [pii]
AID - 10.1016/j.biomaterials.2010.03.048 [doi]
PST - ppublish
SO  - Biomaterials. 2010 Jul;31(21):5564-74. doi: 10.1016/j.biomaterials.2010.03.048. 
      Epub 2010 Apr 24.