PMID- 20427188 OWN - NLM STAT- MEDLINE DCOM- 20101124 LR - 20100531 IS - 1532-2653 (Electronic) IS - 0967-5868 (Linking) VI - 17 IP - 7 DP - 2010 Jul TI - Oncomodulatory mechanisms of human cytomegalovirus in gliomas. PG - 819-23 LID - 10.1016/j.jocn.2009.10.040 [doi] AB - Human cytomegalovirus (HCMV), a widespread beta-herpes virus, infects a high percentage of high grade gliomas. Although HCMV is not recognized as an oncogenic virus, it might increase the malignancy of the infected cell by disrupting cellular pathways involved in the cell cycle, apoptosis, angiogenesis, cell invasion and the host immune response. This article reviews the recent evidence of the modulatory effects of HCMV infection leading to the malignant progression of gliomas and explores novel therapeutic targets against such lethal tumors. FAU - Barami, Kaveh AU - Barami K AD - Memorial Neuroscience Center, Memorial Hospital Jacksonville, Suite 355, Jacksonville, Florida 32216, USA. kbarami@yahoo.com LA - eng PT - Journal Article PT - Review DEP - 20100427 PL - Scotland TA - J Clin Neurosci JT - Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia JID - 9433352 RN - 0 (Antineoplastic Agents) SB - IM MH - Animals MH - Antineoplastic Agents/therapeutic use MH - Cell Cycle/drug effects/physiology MH - Cell Movement/drug effects/physiology MH - Cytomegalovirus/drug effects/*pathogenicity MH - Cytomegalovirus Infections/drug therapy/*pathology/*virology MH - Glioma/drug therapy/*pathology/*virology MH - Humans RF - 64 EDAT- 2010/04/30 06:00 MHDA- 2010/12/14 06:00 CRDT- 2010/04/30 06:00 PHST- 2009/10/18 00:00 [received] PHST- 2009/10/25 00:00 [accepted] PHST- 2010/04/30 06:00 [entrez] PHST- 2010/04/30 06:00 [pubmed] PHST- 2010/12/14 06:00 [medline] AID - S0967-5868(10)00074-3 [pii] AID - 10.1016/j.jocn.2009.10.040 [doi] PST - ppublish SO - J Clin Neurosci. 2010 Jul;17(7):819-23. doi: 10.1016/j.jocn.2009.10.040. Epub 2010 Apr 27.