PMID- 20442368
OWN - NLM
STAT- MEDLINE
DCOM- 20100907
LR  - 20211020
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 116
IP  - 5
DP  - 2010 Aug 5
TI  - Mutations of the Wilms tumor 1 gene (WT1) in older patients with primary 
      cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B 
      study.
PG  - 788-92
LID - 10.1182/blood-2010-01-262543 [doi]
AB  - We previously reported the adverse prognostic impact of Wilms tumor 1 gene (WT1) 
      mutations in younger adult cytogenetically normal acute myeloid leukemia 
      (CN-AML). Here, we investigated 243 older (> or = 60 years) primary CN-AML 
      patients. WT1 mutated (WT1mut) patients (7%) had FLT3-ITD more frequently (P < 
      .001), lower hemoglobin (P = .01), higher white blood cell count (P = .03) and 
      percentage blood blasts (P = .03), and a shorter overall survival (P = .08) than 
      WT1 wild-type (WT1wt) patients. Comparing older and younger WT1mut patients, they 
      had similar pretreatment characteristics and outcome. By contrast, among WT1wt 
      CN-AML, younger patients had a significantly better outcome. A WT1 
      mutation-associated gene-expression signature, reported here for the first time, 
      included CD96, a leukemia stem cell-specific marker, and genes involved in gene 
      regulation (eg, MLL, PML, and SNRPN) and in proliferative and metabolic processes 
      (eg, INSR, IRS2, and PRKAA1), supporting the role of mutated WT1 in deregulating 
      multiple homeostatic processes. Our results indicate that WT1mut CN-AML 
      represents a distinct entity with poor treatment response across age groups. This 
      study has been registered at www.clinicaltrials.gov as #NCT00900224.
FAU - Becker, Heiko
AU  - Becker H
AD  - Division of Hematology and Oncology, Department of Internal Medicine, 
      Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
FAU - Marcucci, Guido
AU  - Marcucci G
FAU - Maharry, Kati
AU  - Maharry K
FAU - Radmacher, Michael D
AU  - Radmacher MD
FAU - Mrozek, Krzysztof
AU  - Mrozek K
FAU - Margeson, Dean
AU  - Margeson D
FAU - Whitman, Susan P
AU  - Whitman SP
FAU - Paschka, Peter
AU  - Paschka P
FAU - Holland, Kelsi B
AU  - Holland KB
FAU - Schwind, Sebastian
AU  - Schwind S
FAU - Wu, Yue-Zhong
AU  - Wu YZ
FAU - Powell, Bayard L
AU  - Powell BL
FAU - Carter, Thomas H
AU  - Carter TH
FAU - Kolitz, Jonathan E
AU  - Kolitz JE
FAU - Wetzler, Meir
AU  - Wetzler M
FAU - Carroll, Andrew J
AU  - Carroll AJ
FAU - Baer, Maria R
AU  - Baer MR
FAU - Moore, Joseph O
AU  - Moore JO
FAU - Caligiuri, Michael A
AU  - Caligiuri MA
FAU - Larson, Richard A
AU  - Larson RA
FAU - Bloomfield, Clara D
AU  - Bloomfield CD
LA  - eng
SI  - ClinicalTrials.gov/NCT00900224
GR  - U10 CA033601/CA/NCI NIH HHS/United States
GR  - U24 CA114725/CA/NCI NIH HHS/United States
GR  - U10 CA101140/CA/NCI NIH HHS/United States
GR  - P30 CA016058/CA/NCI NIH HHS/United States
GR  - CA77658/CA/NCI NIH HHS/United States
GR  - CA31946/CA/NCI NIH HHS/United States
GR  - CA140158/CA/NCI NIH HHS/United States
GR  - CA33601/CA/NCI NIH HHS/United States
GR  - P50 CA140158/CA/NCI NIH HHS/United States
GR  - CA16058/CA/NCI NIH HHS/United States
GR  - CA101140/CA/NCI NIH HHS/United States
GR  - U10 CA077658/CA/NCI NIH HHS/United States
GR  - U10 CA031946/CA/NCI NIH HHS/United States
GR  - R21 CA129657/CA/NCI NIH HHS/United States
GR  - CA129657/CA/NCI NIH HHS/United States
GR  - CA114725/CA/NCI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
DEP - 20100504
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Neoplasm Proteins)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Cohort Studies
MH  - DNA Mutational Analysis
MH  - Female
MH  - *Gene Expression Profiling
MH  - *Gene Expression Regulation, Leukemic
MH  - *Genes, Wilms Tumor
MH  - Homeostasis/genetics
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Leukemia, Myeloid/*genetics/mortality
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Proteins/biosynthesis/genetics
MH  - Prognosis
MH  - Survival Analysis
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC2918333
EDAT- 2010/05/06 06:00
MHDA- 2010/09/08 06:00
PMCR- 2011/08/05
CRDT- 2010/05/06 06:00
PHST- 2010/05/06 06:00 [entrez]
PHST- 2010/05/06 06:00 [pubmed]
PHST- 2010/09/08 06:00 [medline]
PHST- 2011/08/05 00:00 [pmc-release]
AID - S0006-4971(20)34675-9 [pii]
AID - 2010/262543 [pii]
AID - 10.1182/blood-2010-01-262543 [doi]
PST - ppublish
SO  - Blood. 2010 Aug 5;116(5):788-92. doi: 10.1182/blood-2010-01-262543. Epub 2010 May 
      4.