PMID- 20466548
OWN - NLM
STAT- MEDLINE
DCOM- 20101124
LR  - 20100531
IS  - 1532-2653 (Electronic)
IS  - 0967-5868 (Linking)
VI  - 17
IP  - 7
DP  - 2010 Jul
TI  - Autologous tumor cell vaccination plus infusion of GM-CSF by a programmable pump 
      in the treatment of recurrent malignant gliomas.
PG  - 842-8
LID - 10.1016/j.jocn.2009.11.017 [doi]
AB  - We report on the safety and feasibility of autologous tumor cell vaccination 
      combined with infusion of granulocyte-macrophage colony-stimulating factor by a 
      programmable pump in the treatment of recurrent malignant gliomas. The 
      programmable pump is a promising tool used to infuse cytokines subcutaneously for 
      vaccination. Our trial enrolled nine patients who had undergone surgery, 
      radiation and had been successfully weaned off steroids. Unfortunately, only five 
      patients completed the protocol and were monitored for side effects, local 
      reactions, delayed-type hypersensitivity (DTH) responses and survival. The 
      treatment was well tolerated. Two patients developed DTH reactions after 
      vaccination and three patients had an unusually long survival without any other 
      treatment. Despite the few patients treated, the results of this trial are 
      encouraging. This study also highlights the specific difficulties encountered in 
      vaccination programs for the treatment of glioma.
FAU - Clavreul, Anne
AU  - Clavreul A
AD  - Departement de Neurochirurgie, Centre Hospitalier Universitaire (CHU), 4 rue 
      Larrey, Angers, France. anne.clavreul@univ-angers.fr
FAU - Piard, Nicole
AU  - Piard N
FAU - Tanguy, Jean-Yves
AU  - Tanguy JY
FAU - Gamelin, Eric
AU  - Gamelin E
FAU - Rousselet, Marie-Christine
AU  - Rousselet MC
FAU - Leynia, Pierre
AU  - Leynia P
FAU - Menei, Philippe
AU  - Menei P
LA  - eng
PT  - Clinical Trial, Phase I
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100513
PL  - Scotland
TA  - J Clin Neurosci
JT  - Journal of clinical neuroscience : official journal of the Neurosurgical Society 
      of Australasia
JID - 9433352
RN  - 0 (Cancer Vaccines)
RN  - 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain Neoplasms/*drug therapy/prevention & control
MH  - Cancer Vaccines/*therapeutic use
MH  - Combined Modality Therapy
MH  - Female
MH  - Glioma/*drug therapy/prevention & control
MH  - Granulocyte-Macrophage Colony-Stimulating Factor/*administration & 
      dosage/therapeutic use
MH  - Humans
MH  - Immunotherapy, Adoptive/instrumentation/methods
MH  - *Infusion Pumps, Implantable
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/*drug therapy/prevention & control
MH  - Treatment Outcome
MH  - Tumor Cells, Cultured
EDAT- 2010/05/15 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/05/15 06:00
PHST- 2009/09/29 00:00 [received]
PHST- 2009/11/10 00:00 [revised]
PHST- 2009/11/17 00:00 [accepted]
PHST- 2010/05/15 06:00 [entrez]
PHST- 2010/05/15 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0967-5868(10)00047-0 [pii]
AID - 10.1016/j.jocn.2009.11.017 [doi]
PST - ppublish
SO  - J Clin Neurosci. 2010 Jul;17(7):842-8. doi: 10.1016/j.jocn.2009.11.017. Epub 2010 
      May 13.