PMID- 20484518
OWN - NLM
STAT- MEDLINE
DCOM- 20100720
LR  - 20211020
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Print)
IS  - 0022-538X (Linking)
VI  - 84
IP  - 15
DP  - 2010 Aug
TI  - Downregulation of robust acute type I interferon responses distinguishes 
      nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from 
      pathogenic SIV infection of rhesus macaques.
PG  - 7886-91
LID - 10.1128/JVI.02612-09 [doi]
AB  - The mechanisms underlying the AIDS resistance of natural hosts for simian 
      immunodeficiency virus (SIV) remain unknown. Recently, it was proposed that 
      natural SIV hosts avoid disease because their plasmacytoid dendritic cells (pDCs) 
      are intrinsically unable to produce alpha interferon (IFN-alpha) in response to 
      SIV RNA stimulation. However, here we show that (i) acute SIV infections of 
      natural hosts are associated with a rapid and robust type I IFN response in vivo, 
      (ii) pDCs are the principal in vivo producers of IFN-alpha/beta at peak acute 
      infection in lymphatic tissues, and (iii) natural SIV hosts downregulate these 
      responses in early chronic infection. In contrast, persistently high type I IFN 
      responses are observed during pathogenic SIV infection of rhesus macaques.
FAU - Harris, Levelle D
AU  - Harris LD
AD  - Laboratory of Molecular Microbiology, NIAID, NIH, Bethesda, Maryland, USA.
FAU - Tabb, Brian
AU  - Tabb B
FAU - Sodora, Donald L
AU  - Sodora DL
FAU - Paiardini, Mirko
AU  - Paiardini M
FAU - Klatt, Nichole R
AU  - Klatt NR
FAU - Douek, Daniel C
AU  - Douek DC
FAU - Silvestri, Guido
AU  - Silvestri G
FAU - Muller-Trutwin, Michaela
AU  - Muller-Trutwin M
FAU - Vasile-Pandrea, Ivona
AU  - Vasile-Pandrea I
FAU - Apetrei, Cristian
AU  - Apetrei C
FAU - Hirsch, Vanessa
AU  - Hirsch V
FAU - Lifson, Jeffrey
AU  - Lifson J
FAU - Brenchley, Jason M
AU  - Brenchley JM
FAU - Estes, Jacob D
AU  - Estes JD
LA  - eng
GR  - HHSN261200800001C/RC/CCR NIH HHS/United States
GR  - HHSN261200800001E/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100519
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Interferon Type I)
SB  - IM
MH  - Animals
MH  - Chlorocebus aethiops
MH  - Dendritic Cells/*immunology
MH  - Down-Regulation
MH  - Humans
MH  - Interferon Type I/*immunology
MH  - Macaca mulatta
MH  - Simian Acquired Immunodeficiency Syndrome/*immunology/*pathology/virology
MH  - Simian Immunodeficiency Virus/*immunology/*pathogenicity
PMC - PMC2897601
EDAT- 2010/05/21 06:00
MHDA- 2010/07/21 06:00
PMCR- 2011/02/01
CRDT- 2010/05/21 06:00
PHST- 2010/05/21 06:00 [entrez]
PHST- 2010/05/21 06:00 [pubmed]
PHST- 2010/07/21 06:00 [medline]
PHST- 2011/02/01 00:00 [pmc-release]
AID - JVI.02612-09 [pii]
AID - 2612-09 [pii]
AID - 10.1128/JVI.02612-09 [doi]
PST - ppublish
SO  - J Virol. 2010 Aug;84(15):7886-91. doi: 10.1128/JVI.02612-09. Epub 2010 May 19.