PMID- 20495575
OWN - NLM
STAT- MEDLINE
DCOM- 20100603
LR  - 20220408
IS  - 1474-1768 (Electronic)
IS  - 1474-175X (Linking)
VI  - 10
IP  - 6
DP  - 2010 Jun
TI  - TGFbeta signalling: a complex web in cancer progression.
PG  - 415-24
LID - 10.1038/nrc2853 [doi]
AB  - The distortion of growth factor signalling is the most important prerequisite in 
      tumour progression. Transforming growth factor-beta (TGFbeta) signalling 
      regulates tumour progression by a tumour cell-autonomous mechanism or through 
      tumour-stroma interaction, and has either a tumour-suppressing or 
      tumour-promoting function depending on cellular context. Such inherent complexity 
      of TGFbeta signalling results in arduous, but promising, assignments for 
      developing therapeutic strategies against malignant tumours. As numerous cellular 
      context-dependent factors tightly maintain the balance of TGFbeta signalling and 
      contribute to the regulation of TGFbeta-induced cell responses, in this Review we 
      discuss how they maintain the balance of TGFbeta signalling and how their 
      collapse leads to tumour progression.
FAU - Ikushima, Hiroaki
AU  - Ikushima H
AD  - Department of Molecular Pathology, Graduate School of Medicine, University of 
      Tokyo, Tokyo 113-0033, Japan.
FAU - Miyazono, Kohei
AU  - Miyazono K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Nat Rev Cancer
JT  - Nature reviews. Cancer
JID - 101124168
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Animals
MH  - *Disease Progression
MH  - Humans
MH  - Neoplasm Metastasis
MH  - Neoplasms/blood supply/genetics/*metabolism/*pathology
MH  - Neovascularization, Pathologic
MH  - *Signal Transduction
MH  - Transforming Growth Factor beta/genetics/*metabolism
RF  - 129
EDAT- 2010/05/25 06:00
MHDA- 2010/06/04 06:00
CRDT- 2010/05/25 06:00
PHST- 2010/05/25 06:00 [entrez]
PHST- 2010/05/25 06:00 [pubmed]
PHST- 2010/06/04 06:00 [medline]
AID - nrc2853 [pii]
AID - 10.1038/nrc2853 [doi]
PST - ppublish
SO  - Nat Rev Cancer. 2010 Jun;10(6):415-24. doi: 10.1038/nrc2853.