PMID- 20503397
OWN - NLM
STAT- MEDLINE
DCOM- 20100615
LR  - 20131121
IS  - 1097-0045 (Electronic)
IS  - 0270-4137 (Linking)
VI  - 70
IP  - 10
DP  - 2010 Jul 1
TI  - Combined inhibitory effects of soy isoflavones and curcumin on the production of 
      prostate-specific antigen.
PG  - 1127-33
LID - 10.1002/pros.21147 [doi]
AB  - BACKGROUND: Sustained chronic inflammation in the prostate promotes prostate 
      carcinogenesis. Since an elevated level of prostate-specific antigen (PSA) per se 
      reflects the presence of inflammation in the prostate, intervention to improve 
      the PSA value might potentially have beneficial effects for the prevention of the 
      development of prostate cancer. Isoflavones and curcumin have anti-inflammatory 
      and anti-oxidant properties. We examined the biological effects of soy 
      isoflavones and curcumin on LNCaP cells. After that, we conducted a clinical 
      trial for men who received prostate biopsies, but were not found to have prostate 
      cancer, to evaluate the effects of soy isoflavones and curcumin on serum PSA 
      levels. METHODS: The expression of androgen receptor and PSA were examined in 
      LNCaP cells before and after treatment of isoflavones and/or curcumin. 
      Eighty-five participants were randomized to take a supplement containing 
      isoflavones and curcumin or placebo daily in a double-blind study. Subjects were 
      subdivided by the cut-off of their baseline PSA value at 10 microg/ml. We 
      evaluated values of PSA before and 6 months after treatment. RESULTS: The 
      production of PSA were markedly decreased by the combined treatment of 
      isoflavones and curcumin in prostate cancer cell line, LNCaP. The expression of 
      the androgen receptor was also suppressed by the treatment. In clinical trials, 
      PSA levels decreased in the patients group with PSA >or= 10 treated with 
      supplement containing isoflavones and curcumin (P = 0.01). CONCLUSIONS: Our 
      results indicated that isoflavones and curcumin could modulate serum PSA levels. 
      Curcumin presumably synergizes with isoflavones to suppress PSA production in 
      prostate cells through the anti-androgen effects.
FAU - Ide, Hisamitsu
AU  - Ide H
AD  - Department of Urology, Teikyo University School of Medicine, Itabashi-ku, Tokyo, 
      Japan.
FAU - Tokiwa, Shino
AU  - Tokiwa S
FAU - Sakamaki, Kentaro
AU  - Sakamaki K
FAU - Nishio, Koujiro
AU  - Nishio K
FAU - Isotani, Shuji
AU  - Isotani S
FAU - Muto, Satoru
AU  - Muto S
FAU - Hama, Takanori
AU  - Hama T
FAU - Masuda, Hiroko
AU  - Masuda H
FAU - Horie, Shigeo
AU  - Horie S
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Prostate
JT  - The Prostate
JID - 8101368
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Isoflavones)
RN  - 0 (Receptors, Androgen)
RN  - EC 3.4.21.77 (Prostate-Specific Antigen)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
MH  - Antineoplastic Combined Chemotherapy Protocols/*administration & dosage
MH  - Blotting, Western
MH  - Cell Line, Tumor
MH  - Curcumin/administration & dosage/*pharmacology
MH  - Double-Blind Method
MH  - Humans
MH  - Isoflavones/administration & dosage/*pharmacology
MH  - Male
MH  - Middle Aged
MH  - Prostate-Specific Antigen/*antagonists & inhibitors/biosynthesis/blood
MH  - Prostatic Neoplasms/blood/*drug therapy/metabolism
MH  - Receptors, Androgen/biosynthesis/blood
EDAT- 2010/05/27 06:00
MHDA- 2010/06/16 06:00
CRDT- 2010/05/27 06:00
PHST- 2010/05/27 06:00 [entrez]
PHST- 2010/05/27 06:00 [pubmed]
PHST- 2010/06/16 06:00 [medline]
AID - 10.1002/pros.21147 [doi]
PST - ppublish
SO  - Prostate. 2010 Jul 1;70(10):1127-33. doi: 10.1002/pros.21147.