PMID- 20510870
OWN - NLM
STAT- MEDLINE
DCOM- 20100621
LR  - 20220411
IS  - 1097-4180 (Electronic)
IS  - 1074-7613 (Linking)
VI  - 32
IP  - 5
DP  - 2010 May 28
TI  - Alternative activation of macrophages: mechanism and functions.
PG  - 593-604
LID - 10.1016/j.immuni.2010.05.007 [doi]
AB  - The concept of an alternative pathway of macrophage activation has stimulated 
      interest in its definition, mechanism, and functional significance in homeostasis 
      and disease. We assess recent research in this field, argue for a restricted 
      definition, and explore pathways by which the T helper 2 (Th2) cell cytokines 
      interleukin-4 (IL-4) and IL-13 mediate their effects on macrophage cell biology, 
      their biosynthesis, and responses to a normal and pathological microenvironment. 
      The stage is now set to gain deeper insights into the role of alternatively 
      activated macrophages in immunobiology.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Gordon, Siamon
AU  - Gordon S
AD  - Sir William Dunn School of Pathology, University of Oxford, South Parks Road, 
      Oxford OX1 3RE, UK. siamon.gordon@path.ox.ac.uk
FAU - Martinez, Fernando O
AU  - Martinez FO
LA  - eng
GR  - G0600727/MRC_/Medical Research Council/United Kingdom
GR  - BHF_/British Heart Foundation/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (Cytokines)
RN  - 0 (Receptors, Interleukin)
SB  - IM
MH  - Animals
MH  - Cytokines/immunology
MH  - Humans
MH  - Macrophage Activation/drug effects/*immunology
MH  - Macrophages/*immunology/metabolism
MH  - Models, Biological
MH  - Neoplasms/immunology/*physiopathology
MH  - Receptors, Interleukin/immunology
MH  - Signal Transduction
RF  - 118
EDAT- 2010/06/01 06:00
MHDA- 2010/06/22 06:00
CRDT- 2010/06/01 06:00
PHST- 2010/04/15 00:00 [received]
PHST- 2010/05/10 00:00 [revised]
PHST- 2010/05/10 00:00 [accepted]
PHST- 2010/06/01 06:00 [entrez]
PHST- 2010/06/01 06:00 [pubmed]
PHST- 2010/06/22 06:00 [medline]
AID - S1074-7613(10)00173-1 [pii]
AID - 10.1016/j.immuni.2010.05.007 [doi]
PST - ppublish
SO  - Immunity. 2010 May 28;32(5):593-604. doi: 10.1016/j.immuni.2010.05.007.