PMID- 20532840
OWN - NLM
STAT- MEDLINE
DCOM- 20100927
LR  - 20211020
IS  - 1865-3774 (Electronic)
IS  - 0925-5710 (Linking)
VI  - 91
IP  - 5
DP  - 2010 Jun
TI  - Evi-1 as a critical regulator of leukemic cells.
PG  - 753-7
LID - 10.1007/s12185-010-0618-5 [doi]
AB  - Ecotropic viral integration site-1 (EVI-1) has been recognized as one of the 
      dominant oncogenes associated with murine and human myeloid leukemia. Recent 
      clinical studies demonstrated that high EVI-1 expression was an independent 
      negative prognostic indicator of survival in leukemia patients. In addition, 
      gene-targeting studies in mice reveal that Evi-1 is preferentially expressed in 
      hematopoietic stem cells (HSCs) and plays an essential role in 
      proliferation/maintenance of HSCs. Proteins associated with EVI-1, signaling 
      pathways regulated by EVI-1, and downstream mediators of EVI-1 transcriptional 
      regulation have been described and characterized. In this study, we summarize 
      current knowledge regarding biochemical properties and biological functions of 
      EVI-1, which provides a foundation for the development of novel therapeutic 
      strategies.
FAU - Goyama, Susumu
AU  - Goyama S
AD  - Department of Hematology and Oncology, Graduate School of Medicine, University of 
      Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
FAU - Kurokawa, Mineo
AU  - Kurokawa M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100608
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (MDS1 and EVI1 Complex Locus Protein)
RN  - 0 (MECOM protein, human)
RN  - 0 (Mecom protein, mouse)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - DNA-Binding Proteins/*genetics/*metabolism
MH  - Gene Expression Regulation, Neoplastic/drug effects
MH  - Hematopoietic Stem Cells/metabolism/*pathology
MH  - Humans
MH  - Leukemia/drug therapy/*genetics/*metabolism
MH  - MDS1 and EVI1 Complex Locus Protein
MH  - Proto-Oncogenes/*genetics
MH  - Transcription Factors/*genetics/*metabolism
RF  - 33
EDAT- 2010/06/10 06:00
MHDA- 2010/09/29 06:00
CRDT- 2010/06/10 06:00
PHST- 2009/08/03 00:00 [received]
PHST- 2010/05/21 00:00 [accepted]
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/09/29 06:00 [medline]
AID - 10.1007/s12185-010-0618-5 [doi]
PST - ppublish
SO  - Int J Hematol. 2010 Jun;91(5):753-7. doi: 10.1007/s12185-010-0618-5. Epub 2010 
      Jun 8.