PMID- 20570935
OWN - NLM
STAT- MEDLINE
DCOM- 20100713
LR  - 20240318
IS  - 1477-9129 (Electronic)
IS  - 0950-1991 (Print)
IS  - 0950-1991 (Linking)
VI  - 137
IP  - 14
DP  - 2010 Jul
TI  - Modelling the Bicoid gradient.
PG  - 2253-64
LID - 10.1242/dev.032409 [doi]
AB  - Morphogen gradients provide embryonic tissues with positional information by 
      inducing target genes at different concentration thresholds and thus at different 
      positions. The Bicoid morphogen gradient in Drosophila melanogaster embryos has 
      recently been analysed quantitatively, yet how it forms remains a matter of 
      controversy. Several biophysical models that rely on production, diffusion and 
      degradation have been formulated to account for the observed dynamics of the 
      Bicoid gradient, but no one model can account for all its characteristics. Here, 
      we discuss how existing data on this gradient fit the various proposed models and 
      what aspects of gradient formation these models fail to explain. We suggest that 
      knowing a few additional parameters, such as the lifetime of Bicoid, would help 
      to identify and develop better models of Bicoid gradient formation.
FAU - Grimm, Oliver
AU  - Grimm O
AD  - Howard Hughes Medical Institute, Department of Molecular Biology, Princeton 
      University, Princeton, NJ 08544, USA. ogrimm@princeton.edu
FAU - Coppey, Mathieu
AU  - Coppey M
FAU - Wieschaus, Eric
AU  - Wieschaus E
LA  - eng
GR  - Howard Hughes Medical Institute/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
SB  - IM
MH  - Animals
MH  - Diffusion
MH  - Drosophila melanogaster/*embryology/genetics/metabolism
MH  - *Models, Biological
PMC - PMC2889599
EDAT- 2010/06/24 06:00
MHDA- 2010/07/14 06:00
PMCR- 2011/07/15
CRDT- 2010/06/24 06:00
PHST- 2010/06/24 06:00 [entrez]
PHST- 2010/06/24 06:00 [pubmed]
PHST- 2010/07/14 06:00 [medline]
PHST- 2011/07/15 00:00 [pmc-release]
AID - 137/14/2253 [pii]
AID - 10.1242/dev.032409 [doi]
PST - ppublish
SO  - Development. 2010 Jul;137(14):2253-64. doi: 10.1242/dev.032409.