PMID- 20601954
OWN - NLM
STAT- MEDLINE
DCOM- 20100813
LR  - 20220408
IS  - 1546-1718 (Electronic)
IS  - 1061-4036 (Linking)
VI  - 42
IP  - 8
DP  - 2010 Aug
TI  - Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic 
      syndromes.
PG  - 665-7
LID - 10.1038/ng.620 [doi]
AB  - In myelodysplastic syndromes (MDS), deletions of chromosome 7 or 7q are common 
      and correlate with a poor prognosis. The relevant genes on chromosome 7 are 
      unknown. We report here that EZH2, located at 7q36.1, is frequently targeted in 
      MDS. Analysis of EZH2 deletions, missense and frameshift mutations strongly 
      suggests that EZH2 is a tumor suppressor. As EZH2 functions as a histone 
      methyltransferase, abnormal histone modification may contribute to epigenetic 
      deregulation in MDS.
FAU - Nikoloski, Gorica
AU  - Nikoloski G
AD  - Department of Laboratory Medicine, Radboud University, Nijmegen Medical Centre, 
      Nijmegen, The Netherlands.
FAU - Langemeijer, Saskia M C
AU  - Langemeijer SM
FAU - Kuiper, Roland P
AU  - Kuiper RP
FAU - Knops, Ruth
AU  - Knops R
FAU - Massop, Marion
AU  - Massop M
FAU - Tonnissen, Evelyn R L T M
AU  - Tonnissen ER
FAU - van der Heijden, Adrian
AU  - van der Heijden A
FAU - Scheele, Theresia N
AU  - Scheele TN
FAU - Vandenberghe, Peter
AU  - Vandenberghe P
FAU - de Witte, Theo
AU  - de Witte T
FAU - van der Reijden, Bert A
AU  - van der Reijden BA
FAU - Jansen, Joop H
AU  - Jansen JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100704
PL  - United States
TA  - Nat Genet
JT  - Nature genetics
JID - 9216904
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Transcription Factors)
RN  - EC 2.1.1.- (Histone Methyltransferases)
RN  - EC 2.1.1.43 (EZH2 protein, human)
RN  - EC 2.1.1.43 (Enhancer of Zeste Homolog 2 Protein)
RN  - EC 2.1.1.43 (Histone-Lysine N-Methyltransferase)
RN  - EC 2.1.1.43 (Polycomb Repressive Complex 2)
SB  - IM
MH  - DNA-Binding Proteins
MH  - Enhancer of Zeste Homolog 2 Protein
MH  - Genes, Tumor Suppressor
MH  - Histone Methyltransferases
MH  - Histone-Lysine N-Methyltransferase
MH  - Humans
MH  - *Mutation
MH  - Myelodysplastic Syndromes/*genetics
MH  - Polycomb Repressive Complex 2
MH  - Transcription Factors
EDAT- 2010/07/06 06:00
MHDA- 2010/08/14 06:00
CRDT- 2010/07/06 06:00
PHST- 2010/01/15 00:00 [received]
PHST- 2010/05/18 00:00 [accepted]
PHST- 2010/07/06 06:00 [entrez]
PHST- 2010/07/06 06:00 [pubmed]
PHST- 2010/08/14 06:00 [medline]
AID - ng.620 [pii]
AID - 10.1038/ng.620 [doi]
PST - ppublish
SO  - Nat Genet. 2010 Aug;42(8):665-7. doi: 10.1038/ng.620. Epub 2010 Jul 4.