PMID- 20616808
OWN - NLM
STAT- MEDLINE
DCOM- 20100825
LR  - 20220410
IS  - 1474-1784 (Electronic)
IS  - 1474-1776 (Linking)
VI  - 9
IP  - 8
DP  - 2010 Aug
TI  - Strategies in the design of nanoparticles for therapeutic applications.
PG  - 615-27
LID - 10.1038/nrd2591 [doi]
AB  - Engineered nanoparticles have the potential to revolutionize the diagnosis and 
      treatment of many diseases; for example, by allowing the targeted delivery of a 
      drug to particular subsets of cells. However, so far, such nanoparticles have not 
      proved capable of surmounting all of the biological barriers required to achieve 
      this goal. Nevertheless, advances in nanoparticle engineering, as well as 
      advances in understanding the importance of nanoparticle characteristics such as 
      size, shape and surface properties for biological interactions, are creating new 
      opportunities for the development of nanoparticles for therapeutic applications. 
      This Review focuses on recent progress important for the rational design of such 
      nanoparticles and discusses the challenges to realizing the potential of 
      nanoparticles.
FAU - Petros, Robby A
AU  - Petros RA
AD  - Department of Chemistry, University of North Texas, Denton, Texas 76203, USA. 
      petros@unt.edu
FAU - DeSimone, Joseph M
AU  - DeSimone JM
LA  - eng
GR  - P01-GM059299/GM/NIGMS NIH HHS/United States
GR  - U54-CA119343/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20100709
PL  - England
TA  - Nat Rev Drug Discov
JT  - Nature reviews. Drug discovery
JID - 101124171
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - *Drug Delivery Systems
MH  - *Drug Design
MH  - Humans
MH  - *Nanoparticles
MH  - Particle Size
MH  - Pharmaceutical Preparations/administration & dosage
MH  - Surface Properties
RF  - 173
EDAT- 2010/07/10 06:00
MHDA- 2010/08/26 06:00
CRDT- 2010/07/10 06:00
PHST- 2010/07/10 06:00 [entrez]
PHST- 2010/07/10 06:00 [pubmed]
PHST- 2010/08/26 06:00 [medline]
AID - nrd2591 [pii]
AID - 10.1038/nrd2591 [doi]
PST - ppublish
SO  - Nat Rev Drug Discov. 2010 Aug;9(8):615-27. doi: 10.1038/nrd2591. Epub 2010 Jul 9.