PMID- 20620944
OWN - NLM
STAT- MEDLINE
DCOM- 20100812
LR  - 20231213
IS  - 1097-4180 (Electronic)
IS  - 1074-7613 (Print)
IS  - 1074-7613 (Linking)
VI  - 32
IP  - 6
DP  - 2010 Jun 25
TI  - Interleukin-1beta selectively expands and sustains interleukin-22+ immature human 
      natural killer cells in secondary lymphoid tissue.
PG  - 803-14
LID - 10.1016/j.immuni.2010.06.007 [doi]
AB  - Among human natural killer (NK) cell intermediates in secondary lymphoid tissue 
      (SLT), stage 3 CD34(-)CD117(+)CD161(+)CD94(-) immature NK (iNK) cells uniquely 
      express aryl hydrocarbon receptor (AHR) and interleukin-22 (IL-22), supporting a 
      role in mucosal immunity. The mechanisms controlling proliferation and 
      differentiation of these cells are unknown. Here we demonstrate that the IL-1 
      receptor IL-1R1 was selectively expressed by a subpopulation of iNK cells that 
      localized proximal to IL-1beta-producing conventional dendritic cells (cDCs) 
      within SLT. IL-1R1(hi) iNK cells required continuous exposure to IL-1beta to 
      retain AHR and IL-22 expression, and they proliferate in direct response to 
      cDC-derived IL-15 and IL-1beta. In the absence of IL-1beta, a substantially 
      greater fraction of IL-1R1(hi) iNK cells differentiated to stage 4 NK cells and 
      acquired the ability to kill and secrete IFN-gamma. Thus, cDC-derived IL-1beta 
      preserves and expands IL-1R1(hi)IL-22(+)AHR(+) iNK cells, potentially influencing 
      human mucosal innate immunity during infection.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Hughes, Tiffany
AU  - Hughes T
AD  - Integrated Biomedical Graduate Program, The Ohio State University, Columbus, OH 
      43210, USA.
FAU - Becknell, Brian
AU  - Becknell B
FAU - Freud, Aharon G
AU  - Freud AG
FAU - McClory, Susan
AU  - McClory S
FAU - Briercheck, Edward
AU  - Briercheck E
FAU - Yu, Jianhua
AU  - Yu J
FAU - Mao, Charlene
AU  - Mao C
FAU - Giovenzana, Chiara
AU  - Giovenzana C
FAU - Nuovo, Gerard
AU  - Nuovo G
FAU - Wei, Lai
AU  - Wei L
FAU - Zhang, Xiaoli
AU  - Zhang X
FAU - Gavrilin, Mikhail A
AU  - Gavrilin MA
FAU - Wewers, Mark D
AU  - Wewers MD
FAU - Caligiuri, Michael A
AU  - Caligiuri MA
LA  - eng
GR  - CA68458/CA/NCI NIH HHS/United States
GR  - R01 CA068458/CA/NCI NIH HHS/United States
GR  - P01 CA095426/CA/NCI NIH HHS/United States
GR  - P30 CA016058/CA/NCI NIH HHS/United States
GR  - CA95426/CA/NCI NIH HHS/United States
GR  - R37 CA068458/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukins)
RN  - 0 (Receptors, Interleukin-1)
SB  - IM
CIN - Immunity. 2010 Jun 25;32(6):734-6. PMID: 20620939
MH  - Cell Differentiation/*immunology
MH  - Cell Proliferation
MH  - Cell Separation
MH  - Dendritic Cells/immunology/metabolism
MH  - Flow Cytometry
MH  - Humans
MH  - Immunity, Mucosal/immunology
MH  - Immunohistochemistry
MH  - Interleukin-1beta/*immunology/metabolism
MH  - Interleukins/*immunology/metabolism
MH  - Killer Cells, Natural/*cytology/immunology/metabolism
MH  - Lymphoid Tissue/cytology/immunology
MH  - Receptors, Interleukin-1/immunology/metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Interleukin-22
PMC - PMC3742307
MID - NIHMS496905
EDAT- 2010/07/14 06:00
MHDA- 2010/08/13 06:00
PMCR- 2013/08/13
CRDT- 2010/07/13 06:00
PHST- 2009/12/17 00:00 [received]
PHST- 2010/05/03 00:00 [revised]
PHST- 2010/05/20 00:00 [accepted]
PHST- 2010/07/13 06:00 [entrez]
PHST- 2010/07/14 06:00 [pubmed]
PHST- 2010/08/13 06:00 [medline]
PHST- 2013/08/13 00:00 [pmc-release]
AID - S1074-7613(10)00210-4 [pii]
AID - 10.1016/j.immuni.2010.06.007 [doi]
PST - ppublish
SO  - Immunity. 2010 Jun 25;32(6):803-14. doi: 10.1016/j.immuni.2010.06.007.