PMID- 20637861
OWN - NLM
STAT- MEDLINE
DCOM- 20110301
LR  - 20250529
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1812
IP  - 2
DP  - 2011 Feb
TI  - The role of antigen presenting cells in multiple sclerosis.
PG  - 265-74
LID - 10.1016/j.bbadis.2010.07.008 [doi]
AB  - Multiple sclerosis (MS) is a debilitating T cell mediated autoimmune disease of 
      the central nervous system (CNS). Animal models of MS, such as experimental 
      autoimmune encephalomyelitis (EAE) and Theiler's murine encephalomyelitis 
      virus-induced demyelinating disease (TMEV-IDD) have given light to cellular 
      mechanisms involved in the initiation and progression of this organ-specific 
      autoimmune disease. Within the CNS, antigen presenting cells (APC) such as 
      microglia and astrocytes participate as first line defenders against infections 
      or inflammation. However, during chronic inflammation they can participate in 
      perpetuating the self-destructive environment by secretion of inflammatory 
      factors and/or presentation of myelin epitopes to autoreactive T cells. Dendritic 
      cells (DC) are also participants in the presentation of antigen to T cells, even 
      within the CNS. While the APCs alone are not solely responsible for mediating the 
      destruction to the myelin sheath, they are critical players in perpetuating the 
      inflammatory milieu. This review will highlight relevant studies which have 
      provided insight to the roles played by microglia, DCs and astrocytes in the 
      context of CNS autoimmunity.
CI  - 2010 Elsevier B.V. All rights reserved.
FAU - Chastain, Emily M L
AU  - Chastain EM
AD  - Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern 
      University, Chicago, IL, USA.
FAU - Duncan, D'Anne S
AU  - Duncan DS
FAU - Rodgers, Jane M
AU  - Rodgers JM
FAU - Miller, Stephen D
AU  - Miller SD
LA  - eng
GR  - R01 NS030871/NS/NINDS NIH HHS/United States
GR  - T32 AI060523/AI/NIAID NIH HHS/United States
GR  - R01 NS062365/NS/NINDS NIH HHS/United States
GR  - T32 AI060523-06/AI/NIAID NIH HHS/United States
GR  - R01 NS026543/NS/NINDS NIH HHS/United States
GR  - T90 DA022881/DA/NIDA NIH HHS/United States
GR  - F31 NS061621/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100715
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (Cytokines)
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Animals
MH  - Antigen Presentation
MH  - Antigen-Presenting Cells/*immunology
MH  - Astrocytes/immunology
MH  - Cardiovirus Infections/immunology
MH  - Cytokines/biosynthesis
MH  - Demyelinating Diseases/immunology
MH  - Dendritic Cells/immunology
MH  - Encephalomyelitis, Autoimmune, Experimental/immunology
MH  - Humans
MH  - Macrophages/immunology
MH  - Major Histocompatibility Complex
MH  - Mice
MH  - Microglia/immunology
MH  - Multiple Sclerosis/*immunology
MH  - T-Lymphocytes/immunology
MH  - Theilovirus
MH  - Toll-Like Receptors/immunology
PMC - PMC2970677
MID - NIHMS220872
EDAT- 2010/07/20 06:00
MHDA- 2011/03/02 06:00
PMCR- 2012/02/01
CRDT- 2010/07/20 06:00
PHST- 2010/03/13 00:00 [received]
PHST- 2010/07/06 00:00 [revised]
PHST- 2010/07/07 00:00 [accepted]
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2011/03/02 06:00 [medline]
PHST- 2012/02/01 00:00 [pmc-release]
AID - S0925-4439(10)00145-6 [pii]
AID - 10.1016/j.bbadis.2010.07.008 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 2011 Feb;1812(2):265-74. doi: 10.1016/j.bbadis.2010.07.008. 
      Epub 2010 Jul 15.