PMID- 20638054
OWN - NLM
STAT- MEDLINE
DCOM- 20110110
LR  - 20101126
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 94
IP  - 7
DP  - 2010 Dec
TI  - Reduced fertility with impairment of early-stage embryos observed in mice lacking 
      Lgr4 in epithelial tissues.
PG  - 2878-81
LID - 10.1016/j.fertnstert.2010.05.050 [doi]
AB  - Lgr4 is one of the genes identified as novel G protein-coupled receptor genes 
      designated Lgr4-Lgr8, with high homology with FSH receptor, LH receptor, and TSH 
      receptor genes, but studies of Lgr4-mutant mice have suggested that Lgr4 has 
      essential functions in development. This is the first report describing the 
      relationship between the functions of Lgr4 and female reproductive systems.
CI  - Copyright (c) 2010 American Society for Reproductive Medicine. Published by 
      Elsevier Inc. All rights reserved.
FAU - Mohri, Yasuaki
AU  - Mohri Y
AD  - Laboratory of Molecular Biology, Graduate School of Agricultrual Science, Tohoku 
      University, Aoba-ku, Sendai, Japan.
FAU - Umezu, Tomohiro
AU  - Umezu T
FAU - Hidema, Shizu
AU  - Hidema S
FAU - Tomisawa, Hayato
AU  - Tomisawa H
FAU - Akamatsu, Atsushi
AU  - Akamatsu A
FAU - Kato, Shigeki
AU  - Kato S
FAU - Nawa, Akihiro
AU  - Nawa A
FAU - Nishimori, Katsuhiko
AU  - Nishimori K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100717
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
RN  - 0 (LGR4 protein, mouse)
RN  - 0 (Receptors, G-Protein-Coupled)
SB  - IM
MH  - Animals
MH  - Cleavage Stage, Ovum/metabolism
MH  - Down-Regulation
MH  - Embryo, Mammalian
MH  - Embryonic Development/*genetics
MH  - Epithelium/*metabolism
MH  - Fallopian Tubes/metabolism
MH  - Female
MH  - Fertility/*genetics/physiology
MH  - Infertility/*genetics/metabolism/pathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Pregnancy
MH  - Receptors, G-Protein-Coupled/*genetics/metabolism
MH  - Uterus/metabolism/pathology
EDAT- 2010/07/20 06:00
MHDA- 2011/01/11 06:00
CRDT- 2010/07/20 06:00
PHST- 2010/02/04 00:00 [received]
PHST- 2010/05/18 00:00 [revised]
PHST- 2010/05/26 00:00 [accepted]
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2011/01/11 06:00 [medline]
AID - S0015-0282(10)00922-2 [pii]
AID - 10.1016/j.fertnstert.2010.05.050 [doi]
PST - ppublish
SO  - Fertil Steril. 2010 Dec;94(7):2878-81. doi: 10.1016/j.fertnstert.2010.05.050. 
      Epub 2010 Jul 17.