PMID- 20682002
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20220318
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Print)
IS  - 0009-9104 (Linking)
VI  - 162
IP  - 1
DP  - 2010 Oct
TI  - T cells in multiple sclerosis and experimental autoimmune encephalomyelitis.
PG  - 1-11
LID - 10.1111/j.1365-2249.2010.04143.x [doi]
AB  - Multiple sclerosis (MS) is a demyelinating inflammatory disorder of the central 
      nervous system (CNS), which involves autoimmune responses to myelin antigens. 
      Studies in experimental autoimmune encephalomyelitis (EAE), an animal model for 
      MS, have provided convincing evidence that T cells specific for self-antigens 
      mediate pathology in these diseases. Until recently, T helper type 1 (Th1) cells 
      were thought to be the main effector T cells responsible for the autoimmune 
      inflammation. However more recent studies have highlighted an important 
      pathogenic role for CD4(+) T cells that secrete interleukin (IL)-17, termed Th17, 
      but also IL-17-secreting gammadelta T cells in EAE as well as other autoimmune and 
      chronic inflammatory conditions. This has prompted intensive study of the 
      induction, function and regulation of IL-17-producing T cells in MS and EAE. In 
      this paper, we review the contribution of Th1, Th17, gammadelta, CD8(+) and regulatory T 
      cells as well as the possible development of new therapeutic approaches for MS 
      based on manipulating these T cell subtypes.
CI  - (c) 2010 The Authors. Clinical and Experimental Immunology (c) 2010 British Society 
      for Immunology.
FAU - Fletcher, J M
AU  - Fletcher JM
AD  - Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity 
      College, St Vincent's University Hospital, Dublin, Ireland.
FAU - Lalor, S J
AU  - Lalor SJ
FAU - Sweeney, C M
AU  - Sweeney CM
FAU - Tubridy, N
AU  - Tubridy N
FAU - Mills, K H G
AU  - Mills KH
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (Interleukin-17)
SB  - IM
MH  - Animals
MH  - Cell Differentiation/immunology
MH  - Encephalomyelitis, Autoimmune, Experimental/*immunology/pathology
MH  - Humans
MH  - Interleukin-17/immunology/metabolism
MH  - Models, Immunological
MH  - Multiple Sclerosis/*immunology/pathology
MH  - T-Lymphocytes/*immunology/metabolism
MH  - T-Lymphocytes, Helper-Inducer/immunology/metabolism
MH  - Th1 Cells/cytology/*immunology/metabolism
PMC - PMC2990924
EDAT- 2010/08/05 06:00
MHDA- 2010/10/30 06:00
PMCR- 2011/10/01
CRDT- 2010/08/05 06:00
PHST- 2010/08/05 06:00 [entrez]
PHST- 2010/08/05 06:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
PHST- 2011/10/01 00:00 [pmc-release]
AID - CEI4143 [pii]
AID - 10.1111/j.1365-2249.2010.04143.x [doi]
PST - ppublish
SO  - Clin Exp Immunol. 2010 Oct;162(1):1-11. doi: 10.1111/j.1365-2249.2010.04143.x.