PMID- 20682444
OWN - NLM
STAT- MEDLINE
DCOM- 20101112
LR  - 20220825
IS  - 1875-9777 (Electronic)
IS  - 1875-9777 (Linking)
VI  - 7
IP  - 2
DP  - 2010 Aug 6
TI  - Oxygen in stem cell biology: a critical component of the stem cell niche.
PG  - 150-61
LID - 10.1016/j.stem.2010.07.007 [doi]
AB  - The defining hallmark of stem cells is their ability to self-renew and maintain 
      multipotency. This capacity depends on the balance of complex signals in their 
      microenvironment. Low oxygen tensions (hypoxia) maintain undifferentiated states 
      of embryonic, hematopoietic, mesenchymal, and neural stem cell phenotypes and 
      also influence proliferation and cell-fate commitment. Recent evidence has 
      identified a broader spectrum of stem cells influenced by hypoxia that includes 
      cancer stem cells and induced pluripotent stem cells. These findings have 
      important implications on our understanding of development, disease, and 
      tissue-engineering practices and furthermore elucidate an added dimension of stem 
      cell control within the niche.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Mohyeldin, Ahmed
AU  - Mohyeldin A
AD  - Department of Neurosurgery and Oncology, Brain Tumor Stem Cell Laboratory, The 
      Johns Hopkins School of Medicine, Baltimore, MD 21231, USA.
FAU - Garzon-Muvdi, Tomas
AU  - Garzon-Muvdi T
FAU - Quinones-Hinojosa, Alfredo
AU  - Quinones-Hinojosa A
LA  - eng
GR  - K08NS055851/NS/NINDS NIH HHS/United States
GR  - Howard Hughes Medical Institute/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Cell Stem Cell
JT  - Cell stem cell
JID - 101311472
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Animals
MH  - Cell Hypoxia
MH  - Embryonic Development
MH  - Humans
MH  - Neurons/cytology/metabolism
MH  - Oxygen/*metabolism
MH  - Stem Cell Niche/cytology/*metabolism
MH  - Stem Cells/cytology/*metabolism
EDAT- 2010/08/05 06:00
MHDA- 2010/11/13 06:00
CRDT- 2010/08/05 06:00
PHST- 2010/08/05 06:00 [entrez]
PHST- 2010/08/05 06:00 [pubmed]
PHST- 2010/11/13 06:00 [medline]
AID - S1934-5909(10)00341-3 [pii]
AID - 10.1016/j.stem.2010.07.007 [doi]
PST - ppublish
SO  - Cell Stem Cell. 2010 Aug 6;7(2):150-61. doi: 10.1016/j.stem.2010.07.007.