PMID- 20682445
OWN - NLM
STAT- MEDLINE
DCOM- 20101112
LR  - 20220316
IS  - 1875-9777 (Electronic)
IS  - 1934-5909 (Print)
IS  - 1875-9777 (Linking)
VI  - 7
IP  - 2
DP  - 2010 Aug 6
TI  - Adult SVZ lineage cells home to and leave the vascular niche via differential 
      responses to SDF1/CXCR4 signaling.
PG  - 163-73
LID - 10.1016/j.stem.2010.05.019 [doi]
AB  - Neural progenitor cells (NPCs) in the adult subventricular zone (SVZ) are 
      associated with ependymal and vasculature niches, which regulate stem cell 
      self-renewal and differentiation. Activated Type B stem cells and their progeny, 
      the transit-amplifying type C cells, which express EGFR, are most highly 
      associated with vascular cells, indicating that this niche supports lineage 
      progression. Here, we show that proliferative SVZ progenitor cells home to 
      endothelial cells in a stromal-derived factor 1 (SDF1)- and CXC chemokine 
      receptor 4 (CXCR4)-dependent manner. We show that SDF1 strongly upregulates EGFR 
      and alpha6 integrin in activated type B and type C cells, enhancing their 
      activated state and their ability to bind laminin in the vascular niche. SDF1 
      increases the motility of type A neuroblasts, which migrate from the SVZ toward 
      the olfactory bulb. Thus, differential responses to SDF1 can regulate progenitor 
      cell occupancy of and exit from the adult SVZ vascular niche.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Kokovay, Erzsebet
AU  - Kokovay E
AD  - New York Neural Stem Cell Institute, Rensselaer, NY 12144, USA.
FAU - Goderie, Susan
AU  - Goderie S
FAU - Wang, Yue
AU  - Wang Y
FAU - Lotz, Steve
AU  - Lotz S
FAU - Lin, Gang
AU  - Lin G
FAU - Sun, Yu
AU  - Sun Y
FAU - Roysam, Badrinath
AU  - Roysam B
FAU - Shen, Qin
AU  - Shen Q
FAU - Temple, Sally
AU  - Temple S
LA  - eng
GR  - 5T32DA007307/DA/NIDA NIH HHS/United States
GR  - R01 NS051531-05/NS/NINDS NIH HHS/United States
GR  - T32 DA007307/DA/NIDA NIH HHS/United States
GR  - T32 DA007307-08/DA/NIDA NIH HHS/United States
GR  - R01NS051531/NS/NINDS NIH HHS/United States
GR  - R01 NS051531/NS/NINDS NIH HHS/United States
GR  - R01 NS051531-03/NS/NINDS NIH HHS/United States
GR  - T32 DA007307-09/DA/NIDA NIH HHS/United States
GR  - R01 NS051531-04/NS/NINDS NIH HHS/United States
GR  - R01 NS051531-02/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell Stem Cell
JT  - Cell stem cell
JID - 101311472
RN  - 0 (CXCR4 protein, mouse)
RN  - 0 (Chemokine CXCL12)
RN  - 0 (Cxcl12 protein, mouse)
RN  - 0 (Integrins)
RN  - 0 (Receptors, CXCR4)
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
CIN - Cell Stem Cell. 2010 Aug 6;7(2):141-3. PMID: 20682440
MH  - Aging/metabolism
MH  - Animals
MH  - B-Lymphocytes/cytology
MH  - Blood Vessels/cytology
MH  - *Cell Lineage
MH  - Cerebral Ventricles/*blood supply/*cytology
MH  - Chemokine CXCL12/*metabolism
MH  - *Chemotaxis
MH  - Endothelial Cells/metabolism
MH  - ErbB Receptors/metabolism
MH  - Integrins/metabolism
MH  - Lymphocyte Activation
MH  - Mice
MH  - Models, Biological
MH  - Neurons/cytology/metabolism
MH  - Receptors, CXCR4/*metabolism
MH  - *Signal Transduction
MH  - Stem Cell Transplantation
MH  - Stem Cells/cytology/metabolism
PMC - PMC2916873
MID - NIHMS213907
EDAT- 2010/08/05 06:00
MHDA- 2010/11/13 06:00
PMCR- 2011/08/06
CRDT- 2010/08/05 06:00
PHST- 2010/01/11 00:00 [received]
PHST- 2010/04/26 00:00 [revised]
PHST- 2010/05/27 00:00 [accepted]
PHST- 2010/08/05 06:00 [entrez]
PHST- 2010/08/05 06:00 [pubmed]
PHST- 2010/11/13 06:00 [medline]
PHST- 2011/08/06 00:00 [pmc-release]
AID - S1934-5909(10)00279-1 [pii]
AID - 10.1016/j.stem.2010.05.019 [doi]
PST - ppublish
SO  - Cell Stem Cell. 2010 Aug 6;7(2):163-73. doi: 10.1016/j.stem.2010.05.019.