PMID- 20685224
OWN - NLM
STAT- MEDLINE
DCOM- 20110725
LR  - 20220331
IS  - 1872-8294 (Electronic)
IS  - 0169-409X (Linking)
VI  - 63
IP  - 1-2
DP  - 2011 Jan-Feb
TI  - Superparamagnetic iron oxide nanoparticles (SPIONs): development, surface 
      modification and applications in chemotherapy.
PG  - 24-46
LID - 10.1016/j.addr.2010.05.006 [doi]
AB  - At present, nanoparticles are used for various biomedical applications where they 
      facilitate laboratory diagnostics and therapeutics. More specifically for drug 
      delivery purposes, the use of nanoparticles is attracting increasing attention 
      due to their unique capabilities and their negligible side effects not only in 
      cancer therapy but also in the treatment of other ailments. Among all types of 
      nanoparticles, biocompatible superparamagnetic iron oxide nanoparticles (SPIONs) 
      with proper surface architecture and conjugated targeting ligands/proteins have 
      attracted a great deal of attention for drug delivery applications. This review 
      covers recent advances in the development of SPIONs together with their 
      possibilities and limitations from fabrication to application in drug delivery. 
      In addition, the state-of-the-art synthetic routes and surface modification of 
      desired SPIONs for drug delivery purposes are described.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Mahmoudi, Morteza
AU  - Mahmoudi M
AD  - National Cell Bank, Pasteur Institute of Iran, Tehran 1316943551, Iran. 
      mahmoudi@biospion.com
FAU - Sant, Shilpa
AU  - Sant S
FAU - Wang, Ben
AU  - Wang B
FAU - Laurent, Sophie
AU  - Laurent S
FAU - Sen, Tapas
AU  - Sen T
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100526
PL  - Netherlands
TA  - Adv Drug Deliv Rev
JT  - Advanced drug delivery reviews
JID - 8710523
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Magnetite Nanoparticles)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*administration & dosage/*chemistry
MH  - Drug Delivery Systems/*methods
MH  - Humans
MH  - Magnetite Nanoparticles/*administration & dosage/*chemistry
EDAT- 2010/08/06 06:00
MHDA- 2011/07/26 06:00
CRDT- 2010/08/06 06:00
PHST- 2010/04/14 00:00 [received]
PHST- 2010/05/12 00:00 [revised]
PHST- 2010/05/19 00:00 [accepted]
PHST- 2010/08/06 06:00 [entrez]
PHST- 2010/08/06 06:00 [pubmed]
PHST- 2011/07/26 06:00 [medline]
AID - S0169-409X(10)00133-X [pii]
AID - 10.1016/j.addr.2010.05.006 [doi]
PST - ppublish
SO  - Adv Drug Deliv Rev. 2011 Jan-Feb;63(1-2):24-46. doi: 10.1016/j.addr.2010.05.006. 
      Epub 2010 May 26.