PMID- 20691855
OWN - NLM
STAT- MEDLINE
DCOM- 20101110
LR  - 20220330
IS  - 1557-8933 (Electronic)
IS  - 0070-2153 (Linking)
VI  - 90
DP  - 2010
TI  - Eye development.
PG  - 343-86
LID - 10.1016/S0070-2153(10)90010-0 [doi]
AB  - The vertebrate eye comprises tissues from different embryonic origins: the lens 
      and the cornea are derived from the surface ectoderm, but the retina and the 
      epithelial layers of the iris and ciliary body are from the anterior neural 
      plate. The timely action of transcription factors and inductive signals ensure 
      the correct development of the different eye components. Establishing the genetic 
      basis of eye defects in zebrafishes, mouse, and human has been an important tool 
      for the detailed analysis of this complex process. A single eye field forms 
      centrally within the anterior neural plate during gastrulation; it is 
      characterized on the molecular level by the expression of "eye-field 
      transcription factors." The single eye field is separated into two, forming the 
      optic vesicle and later (under influence of the lens placode) the optic cup. The 
      lens develops from the lens placode (surface ectoderm) under influence of the 
      underlying optic vesicle. Pax6 acts in this phase as master control gene, and 
      genes encoding cytoskeletal proteins, structural proteins, or membrane proteins 
      become activated. The cornea forms from the surface ectoderm, and cells from the 
      periocular mesenchyme migrate into the cornea giving rise for the future cornea 
      stroma. Similarly, the iris and ciliary body form from the optic cup. The outer 
      layer of the optic cup becomes the retinal pigmented epithelium, and the main 
      part of the inner layer of the optic cup forms later the neural retina with six 
      different types of cells including the photoreceptors. The retinal ganglion cells 
      grow toward the optic stalk forming the optic nerve. This review describes the 
      major molecular players and cellular processes during eye development as they are 
      known from frogs, zebrafish, chick, and mice-showing also differences among 
      species and missing links for future research. The relevance to human disorders 
      is one of the major aspects covered throughout the review.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Graw, Jochen
AU  - Graw J
AD  - Helmholtz Center Munich-German Research Center for Environmental Health, 
      Institute of Developmental Genetics, Neuherberg, Germany.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Curr Top Dev Biol
JT  - Current topics in developmental biology
JID - 0163114
RN  - 0 (Bone Morphogenetic Proteins)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (Wnt Proteins)
SB  - IM
MH  - Animals
MH  - Bone Morphogenetic Proteins/genetics/metabolism
MH  - Eye/anatomy & histology/*embryology/growth & development
MH  - Gene Expression Regulation, Developmental
MH  - Homeodomain Proteins/genetics/metabolism
MH  - Humans
MH  - *Morphogenesis
MH  - Mutation
MH  - Signal Transduction
MH  - Transcription Factors/genetics/metabolism
MH  - Visual Fields
MH  - Wnt Proteins/genetics/metabolism
EDAT- 2010/08/10 06:00
MHDA- 2010/11/11 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2010/11/11 06:00 [medline]
AID - S0070-2153(10)90010-0 [pii]
AID - 10.1016/S0070-2153(10)90010-0 [doi]
PST - ppublish
SO  - Curr Top Dev Biol. 2010;90:343-86. doi: 10.1016/S0070-2153(10)90010-0.