PMID- 20723761
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20220331
IS  - 1097-4172 (Electronic)
IS  - 0092-8674 (Linking)
VI  - 142
IP  - 4
DP  - 2010 Aug 20
TI  - Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative 
      stress.
PG  - 613-24
LID - 10.1016/j.cell.2010.07.036 [doi]
AB  - Interferon (IFN)-induced immunoproteasomes (i-proteasomes) have been associated 
      with improved processing of major histocompatibility complex (MHC) class I 
      antigens. Here, we show that i-proteasomes function to protect cell viability 
      under conditions of IFN-induced oxidative stress. IFNs trigger the production of 
      reactive oxygen species, which induce protein oxidation and the formation of 
      nascent, oxidant-damaged proteins. We find that the ubiquitylation machinery is 
      concomitantly upregulated in response to IFNs, functioning to target defective 
      ribosomal products (DRiPs) for degradation by i-proteasomes. 
      i-proteasome-deficiency in cells and in murine inflammation models results in the 
      formation of aggresome-like induced structures and increased sensitivity to 
      apoptosis. Efficient clearance of these aggregates by the enhanced proteolytic 
      activity of the i-proteasome is important for the preservation of cell viability 
      upon IFN-induced oxidative stress. Our findings suggest that rather than having a 
      specific role in the production of class I antigens, i-proteasomes increase the 
      peptide supply for antigen presentation as part of a more general role in the 
      maintenance of protein homeostasis.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Seifert, Ulrike
AU  - Seifert U
AD  - Institut fur Biochemie CC2, Charite - Universitatsmedizin Berlin, Oudenarder 
      Strasse 16, D-13347 Berlin, Germany.
FAU - Bialy, Lukasz P
AU  - Bialy LP
FAU - Ebstein, Frederic
AU  - Ebstein F
FAU - Bech-Otschir, Dawadschargal
AU  - Bech-Otschir D
FAU - Voigt, Antje
AU  - Voigt A
FAU - Schroter, Friederike
AU  - Schroter F
FAU - Prozorovski, Timour
AU  - Prozorovski T
FAU - Lange, Nicole
AU  - Lange N
FAU - Steffen, Janos
AU  - Steffen J
FAU - Rieger, Melanie
AU  - Rieger M
FAU - Kuckelkorn, Ulrike
AU  - Kuckelkorn U
FAU - Aktas, Orhan
AU  - Aktas O
FAU - Kloetzel, Peter-M
AU  - Kloetzel PM
FAU - Kruger, Elke
AU  - Kruger E
LA  - eng
SI  - GEO/GSE21760
PT  - Journal Article
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Proteins)
RN  - 9008-11-1 (Interferons)
RN  - EC 3.4.25.1 (Proteasome Endopeptidase Complex)
SB  - IM
CIN - Cell. 2010 Aug 20;142(4):517-8. PMID: 20723753
CIN - Nat Rev Immunol. 2010 Oct;10(10):681. PMID: 20879169
MH  - Animals
MH  - Antigen Presentation
MH  - Encephalomyelitis, Autoimmune, Experimental/immunology/metabolism
MH  - Histocompatibility Antigens Class I/immunology/*metabolism
MH  - Homeostasis
MH  - Humans
MH  - Inflammation/metabolism
MH  - Interferons/*immunology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Proteasome Endopeptidase Complex/*immunology/*metabolism
MH  - Proteins/*metabolism
MH  - Ubiquitination
EDAT- 2010/08/21 06:00
MHDA- 2010/09/16 06:00
CRDT- 2010/08/21 06:00
PHST- 2008/10/31 00:00 [received]
PHST- 2010/04/01 00:00 [revised]
PHST- 2010/06/22 00:00 [accepted]
PHST- 2010/08/21 06:00 [entrez]
PHST- 2010/08/21 06:00 [pubmed]
PHST- 2010/09/16 06:00 [medline]
AID - S0092-8674(10)00840-8 [pii]
AID - 10.1016/j.cell.2010.07.036 [doi]
PST - ppublish
SO  - Cell. 2010 Aug 20;142(4):613-24. doi: 10.1016/j.cell.2010.07.036.