PMID- 20724829
OWN - NLM
STAT- MEDLINE
DCOM- 20110118
LR  - 20211203
IS  - 1551-4005 (Electronic)
IS  - 1551-4005 (Linking)
VI  - 9
IP  - 16
DP  - 2010 Aug 15
TI  - Lgl, the SWH pathway and tumorigenesis: It's a matter of context & competition!
PG  - 3202-12
LID - 10.4161/cc.9.16.12633 [doi]
AB  - Loss of function of the neoplastic tumors suppressors, lgl, scrib and dlg or 
      overexpression of the apical polarity components, Crumbs and atypical protein 
      kinase C (aPKC), are associated with polarity loss and tissue overgrowth, 
      however, the mechanism behind these effects is poorly understood. In our recent 
      study, we showed that Lgl, aPKC and Crumbs mediate their effects on proliferation 
      and survival via the Salvador/Warts/Hippo (SWH) tumor suppressor pathway. Loss of 
      lgl can lead to substantial overgrowth, however the lgl mutant phenotype can be 
      quite variable and the amount of overgrowth of the mutant tissue, its survival 
      and ultimate fate is strongly determined by context and competition. In this 
      extra-view we present a more detailed description of the lgl mutant phenotype and 
      highlight the phenotypic differences between lgl and SWH pathway mutant 
      phenotypes. In addition, we explore the role for the Jun kinase (JNK) pathway in 
      the development of the lgl mutant phenotype.
FAU - Grzeschik, Nicola A
AU  - Grzeschik NA
AD  - Cell Cycle and Development Lab, Peter MacCallum Cancer Centre, University of 
      Melbourne, Melbourne, Victoria, Australia. nico.grzeschik@petermac.org
FAU - Parsons, Linda M
AU  - Parsons LM
FAU - Richardson, Helena E
AU  - Richardson HE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100810
PL  - United States
TA  - Cell Cycle
JT  - Cell cycle (Georgetown, Tex.)
JID - 101137841
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Scrib protein, Drosophila)
RN  - 0 (Tumor Suppressor Proteins)
RN  - 0 (crb protein, Drosophila)
RN  - 0 (l(2)gl protein, Drosophila)
RN  - 0 (sav protein, Drosophila)
RN  - 143513-41-1 (dlg1 protein, Drosophila)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.- (wts protein, Drosophila)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (hpo protein, Drosophila)
RN  - EC 2.7.12.2 (MAP Kinase Kinase 4)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Cell Cycle Proteins/*metabolism
MH  - Drosophila/metabolism
MH  - Drosophila Proteins/genetics/*metabolism/physiology
MH  - Intracellular Signaling Peptides and Proteins/*metabolism
MH  - MAP Kinase Kinase 4/metabolism
MH  - Membrane Proteins/metabolism
MH  - Mutation
MH  - Neoplasms/etiology
MH  - Protein Kinases/*metabolism
MH  - Protein Serine-Threonine Kinases/*metabolism
MH  - Signal Transduction
MH  - Tumor Suppressor Proteins/genetics/*metabolism/physiology
EDAT- 2010/08/21 06:00
MHDA- 2011/01/19 06:00
CRDT- 2010/08/21 06:00
PHST- 2010/08/21 06:00 [entrez]
PHST- 2010/08/21 06:00 [pubmed]
PHST- 2011/01/19 06:00 [medline]
AID - 12633 [pii]
AID - 10.4161/cc.9.16.12633 [doi]
PST - ppublish
SO  - Cell Cycle. 2010 Aug 15;9(16):3202-12. doi: 10.4161/cc.9.16.12633. Epub 2010 Aug 
      10.