PMID- 20929731
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20101029
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 330
IP  - 6004
DP  - 2010 Oct 29
TI  - Lineage relationship analysis of RORgammat+ innate lymphoid cells.
PG  - 665-9
LID - 10.1126/science.1194597 [doi]
AB  - Lymphoid tissue-inducer (LTi) cells initiate the development of lymphoid tissues 
      through the activation of local stromal cells in a process similar to 
      inflammation. LTi cells express the nuclear hormone receptor RORgammat, which also 
      directs the expression of the proinflammatory cytokine interleukin-17 in T cells. 
      We show here that LTi cells are part of a larger family of proinflammatory 
      RORgammat(+) innate lymphoid cells (ILCs) that differentiate from distinct fetal 
      liver RORgammat(+) precursors. The fate of RORgammat(+) ILCs is determined by mouse age, 
      and after birth, favors the generation of cells involved in intestinal 
      homeostasis and defense. Contrary to RORgammat(+) T cells, however, RORgammat(+) ILCs 
      develop in the absence of microbiota. Our study indicates that RORgammat(+) ILCs 
      evolve to preempt intestinal colonization by microbial symbionts.
FAU - Sawa, Shinichiro
AU  - Sawa S
AD  - Lymphoid Tissue Development Unit, Institut Pasteur, 75724 Paris, France.
FAU - Cherrier, Marie
AU  - Cherrier M
FAU - Lochner, Matthias
AU  - Lochner M
FAU - Satoh-Takayama, Naoko
AU  - Satoh-Takayama N
FAU - Fehling, Hans Jorg
AU  - Fehling HJ
FAU - Langa, Francina
AU  - Langa F
FAU - Di Santo, James P
AU  - Di Santo JP
FAU - Eberl, Gerard
AU  - Eberl G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100923
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (CCR6 protein, mouse)
RN  - 0 (Nuclear Receptor Subfamily 1, Group F, Member 3)
RN  - 0 (Receptors, CCR6)
RN  - 0 (Rorc protein, mouse)
SB  - IM
CIN - Science. 2010 Oct 29;330(6004):594-5. PMID: 21030634
MH  - Adaptive Immunity
MH  - Adoptive Transfer
MH  - Animals
MH  - Bacterial Physiological Phenomena
MH  - Cell Differentiation
MH  - Cell Lineage
MH  - Fetus/cytology/immunology/metabolism
MH  - Homeostasis
MH  - Immunity, Mucosal
MH  - Intestinal Mucosa/*immunology
MH  - Intestine, Small/embryology/*immunology/microbiology
MH  - Liver/cytology/embryology/immunology
MH  - Lymphocyte Subsets/cytology/*immunology/metabolism
MH  - Lymphocytes/cytology/*immunology/metabolism
MH  - Lymphoid Progenitor Cells/*cytology
MH  - Lymphoid Tissue/cytology/immunology
MH  - Lymphopoiesis
MH  - Mice
MH  - Mice, Transgenic
MH  - Nuclear Receptor Subfamily 1, Group F, Member 3/*metabolism
MH  - Receptors, CCR6/metabolism
MH  - Symbiosis
MH  - T-Lymphocyte Subsets/cytology/immunology/metabolism
EDAT- 2010/10/12 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/10/09 06:00
PHST- 2010/10/09 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - science.1194597 [pii]
AID - 10.1126/science.1194597 [doi]
PST - ppublish
SO  - Science. 2010 Oct 29;330(6004):665-9. doi: 10.1126/science.1194597. Epub 2010 Sep 
      23.