PMID- 20929733
OWN - NLM
STAT- MEDLINE
DCOM- 20101206
LR  - 20220331
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 330
IP  - 6005
DP  - 2010 Nov 5
TI  - Intestinal stem cell replacement follows a pattern of neutral drift.
PG  - 822-5
LID - 10.1126/science.1196236 [doi]
AB  - With the capacity for rapid self-renewal and regeneration, the intestinal 
      epithelium is stereotypical of stem cell-supported tissues. Yet the pattern of 
      stem cell turnover remains in question. Applying analytical methods from 
      population dynamics and statistical physics to an inducible genetic labeling 
      system, we showed that clone size distributions conform to a distinctive scaling 
      behavior at short times. This result demonstrates that intestinal stem cells form 
      an equipotent population in which the loss of a stem cell is compensated by the 
      multiplication of a neighbor, leading to neutral drift dynamics in which clones 
      expand and contract at random until they either take over the crypt or they are 
      lost. Combined with long-term clonal fate data, we show that the rate of stem 
      cell replacement is comparable to the cell division rate, implying that neutral 
      drift and symmetrical cell divisions are central to stem cell homeostasis.
FAU - Lopez-Garcia, Carlos
AU  - Lopez-Garcia C
AD  - Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson 
      Way, Cambridge CB2 0RE, UK.
FAU - Klein, Allon M
AU  - Klein AM
FAU - Simons, Benjamin D
AU  - Simons BD
FAU - Winton, Douglas J
AU  - Winton DJ
LA  - eng
GR  - G0800784/MRC_/Medical Research Council/United Kingdom
GR  - CRUK_/Cancer Research UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100923
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - *Cell Division
MH  - Cell Lineage
MH  - Clone Cells/cytology
MH  - Colon/cytology
MH  - Homeostasis
MH  - Intestinal Mucosa/*cytology
MH  - Intestine, Small/cytology
MH  - Mice
MH  - Stem Cells/*cytology/physiology
EDAT- 2010/10/12 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/10/09 06:00
PHST- 2010/10/09 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - science.1196236 [pii]
AID - 10.1126/science.1196236 [doi]
PST - ppublish
SO  - Science. 2010 Nov 5;330(6005):822-5. doi: 10.1126/science.1196236. Epub 2010 Sep 
      23.