PMID- 20935475 OWN - NLM STAT- MEDLINE DCOM- 20110302 LR - 20220311 IS - 1551-4005 (Electronic) IS - 1551-4005 (Linking) VI - 9 IP - 19 DP - 2010 Oct 1 TI - LATS tumor suppressor: a new governor of cellular homeostasis. PG - 3892-903 AB - Accumulating evidence points to the LATS (Large Tumor Suppressor) family of human tumor suppressors (LATS1 and LATS2) as new resident governors of cellular homeostasis. Loss of function of either LATS1 or LATS2 leads to a variety of tumor types including soft tissue sarcomas, leukemia, as well as breast, prostate, lung and esophageal cancers. Due to their high degree of homology and functional overlap, LATS1 and LATS2 comprise a new tumor suppressor family. Classically identified within the Hippo-LATS signaling pathway, LATS also acts independently of this pathway, possessing multiple functions including regulation of cell proliferation, cell death and cell migration, as well as broad governing roles such as transcriptional regulation and maintenance of genetic stability. Activity of LATS is tightly controlled through various mechanisms including post-translational modifications, differential localization and expression. Although little is known about the specific underlying mechanisms of these activities, current data suggest that LATS signaling intersects with well-established tumor suppressive or oncogenic pathways including the p53, Ras or Akt networks. This review aims to identify what we know about the LATS tumor suppressor family, highlighting LATS1 and LATS2 redundancies and differences in terms of their structure, expression, regulation and functions, thereby establishing a novel tumor suppressor network. FAU - Visser, Stacy AU - Visser S AD - Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada. FAU - Yang, Xiaolong AU - Yang X LA - eng PT - Journal Article PT - Review DEP - 20101020 PL - United States TA - Cell Cycle JT - Cell cycle (Georgetown, Tex.) JID - 101137841 RN - 0 (Tumor Suppressor Proteins) RN - EC 2.7.1.- (LATS1 protein, human) RN - EC 2.7.1.11 (LATS2 protein, human) RN - EC 2.7.11.1 (Protein Serine-Threonine Kinases) SB - IM MH - Animals MH - Apoptosis MH - Cell Movement MH - Cytoskeleton/metabolism MH - Evolution, Molecular MH - Gene Expression Regulation MH - *Genes, Tumor Suppressor MH - *Homeostasis MH - Humans MH - Neoplasms/genetics/metabolism/pathology MH - Protein Serine-Threonine Kinases/genetics/*metabolism MH - Signal Transduction MH - Tumor Suppressor Proteins/genetics/*metabolism EDAT- 2010/10/12 06:00 MHDA- 2011/03/03 06:00 CRDT- 2010/10/12 06:00 PHST- 2010/10/12 06:00 [entrez] PHST- 2010/10/12 06:00 [pubmed] PHST- 2011/03/03 06:00 [medline] AID - 13386 [pii] AID - 10.4161/cc.9.19.13386 [doi] PST - ppublish SO - Cell Cycle. 2010 Oct 1;9(19):3892-903. doi: 10.4161/cc.9.19.13386. Epub 2010 Oct 20.