PMID- 20936938
OWN - NLM
STAT- MEDLINE
DCOM- 20110425
LR  - 20220408
IS  - 1553-4014 (Electronic)
IS  - 1553-4006 (Linking)
VI  - 6
DP  - 2011
TI  - Mouse models of cancer.
PG  - 95-119
LID - 10.1146/annurev.pathol.3.121806.154244 [doi]
AB  - Genetically engineered mouse models have significantly contributed to our 
      understanding of cancer biology. They have proven to be useful in validating gene 
      functions, identifying novel cancer genes and tumor biomarkers, gaining insight 
      into the molecular and cellular mechanisms underlying tumor initiation and 
      multistage processes of tumorigenesis, and providing better clinical models in 
      which to test novel therapeutic strategies. However, mice still have significant 
      limitations in modeling human cancer, including species-specific differences and 
      inaccurate recapitulation of de novo human tumor development. Future challenges 
      in mouse modeling include the generation of clinically relevant mouse models that 
      recapitulate the molecular, cellular, and genomic events of human cancers and 
      clinical response as well as the development of technologies that allow for 
      efficient in vivo imaging and high-throughput screening in mice.
FAU - Cheon, Dong-Joo
AU  - Cheon DJ
AD  - Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los 
      Angeles, California 90048, USA.
FAU - Orsulic, Sandra
AU  - Orsulic S
LA  - eng
GR  - R01 CA103924/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Annu Rev Pathol
JT  - Annual review of pathology
JID - 101275111
SB  - IM
MH  - Animals
MH  - *Disease Models, Animal
MH  - Humans
MH  - Mice
MH  - *Mice, Transgenic
MH  - *Neoplasms/genetics/physiopathology/therapy
EDAT- 2010/10/13 06:00
MHDA- 2011/04/26 06:00
CRDT- 2010/10/13 06:00
PHST- 2010/10/13 06:00 [entrez]
PHST- 2010/10/13 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - 10.1146/annurev.pathol.3.121806.154244 [doi]
PST - ppublish
SO  - Annu Rev Pathol. 2011;6:95-119. doi: 10.1146/annurev.pathol.3.121806.154244.