PMID- 20945341
OWN - NLM
STAT- MEDLINE
DCOM- 20110302
LR  - 20220408
IS  - 1097-4652 (Electronic)
IS  - 0021-9541 (Linking)
VI  - 226
IP  - 4
DP  - 2011 Apr
TI  - The Hippo pathway in biological control and cancer development.
PG  - 928-39
LID - 10.1002/jcp.22435 [doi]
AB  - The Hippo pathway is an evolutionally conserved protein kinase cascade involved 
      in regulating organ size in vivo and cell contact inhibition in vitro by 
      governing cell proliferation and apoptosis. Deregulation of the Hippo pathway is 
      linked to cancer development. Its first core kinase Warts was identified in 
      Drosophila more than 15 years ago, but it gained much attention when other core 
      components of the pathway were identified 8 years later. Major discoveries of the 
      pathway were made during past several years. The core kinase components Hippo, 
      Salvador, Warts, and Mats in the fly and Mst1/2, WW45, Lats1/2, and Mob1 in 
      mammals phosphorylate and inactivate downstream transcriptional co-activators 
      Yorkie in the fly, Yes-associated protein (YAP) and transcriptional co-activator 
      with PDZ-binding motif (TAZ) in mammals, respectively. Phosphorylated Yorkie, 
      YAP, and TAZ are sequestered in the cytoplasm by interaction with 14-3-3 
      proteins. Here we review recent progresses of this pathway by focusing on how 
      these proteins communicate with each other and how loss of regulation results in 
      cancers.
CI  - Copyright (c) 2010 Wiley-Liss, Inc.
FAU - Chan, Siew Wee
AU  - Chan SW
AD  - Cancer and Developmental Cell Biology Division, Institute of Molecular and Cell 
      Biology, Singapore, Republic of Singapore.
FAU - Lim, Chun Jye
AU  - Lim CJ
FAU - Chen, Liming
AU  - Chen L
FAU - Chong, Yaan Fun
AU  - Chong YF
FAU - Huang, Caixia
AU  - Huang C
FAU - Song, Haiwei
AU  - Song H
FAU - Hong, Wanjin
AU  - Hong W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Cell Physiol
JT  - Journal of cellular physiology
JID - 0050222
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Humans
MH  - Molecular Sequence Data
MH  - Neoplasms/*enzymology/*pathology
MH  - Precancerous Conditions/*enzymology/*pathology
MH  - Protein Serine-Threonine Kinases/chemistry/*metabolism
MH  - *Signal Transduction
MH  - Transcription, Genetic
EDAT- 2010/10/15 06:00
MHDA- 2011/03/03 06:00
CRDT- 2010/10/15 06:00
PHST- 2010/10/15 06:00 [entrez]
PHST- 2010/10/15 06:00 [pubmed]
PHST- 2011/03/03 06:00 [medline]
AID - 10.1002/jcp.22435 [doi]
PST - ppublish
SO  - J Cell Physiol. 2011 Apr;226(4):928-39. doi: 10.1002/jcp.22435.