PMID- 21055975
OWN - NLM
STAT- MEDLINE
DCOM- 20101230
LR  - 20101124
IS  - 1097-4180 (Electronic)
IS  - 1074-7613 (Linking)
VI  - 33
IP  - 5
DP  - 2010 Nov 24
TI  - Regulation of cytokine secretion in human CD127(+) LTi-like innate lymphoid cells 
      by Toll-like receptor 2.
PG  - 752-64
LID - 10.1016/j.immuni.2010.10.012 [doi]
AB  - Lymphoid tissue inducer cells are members of an emerging family of innate 
      lymphoid cells (ILC). Although these cells were originally reported to produce 
      cytokines such as interleukin-17 (IL-17) and IL-22, we demonstrate here that 
      human CD127(+)RORC(+) and CD56(+)CD127(+) LTi-like ILC also express IL-2, IL-5, 
      and IL-13 after activation with physiologic stimuli such as common gamma-chain 
      cytokines, Toll-like receptor (TLR) 2 ligands, or IL-23. Whereas TLR2 signaling 
      induced IL-5, IL-13, and IL-22 expression in a nuclear factor kappaB 
      (NF-kappaB)-dependent manner, IL-23 costimulation induced only IL-22 production. 
      CD127(+) LTi-like ILC displayed clonal heterogeneity for IL-13 and IL-5 
      production, suggesting in vivo polarization. Finally, we identified a role for 
      autocrine IL-2 signaling in mediating the effects of TLR2 stimulation on 
      CD56(+)CD127(+) and CD127(+) LTi-like ILC. These results indicate that human 
      LTi-like ILC can directly sense bacterial components and unravel a previously 
      unrecognized functional heterogeneity among this important population of innate 
      lymphoid cells.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Crellin, Natasha K
AU  - Crellin NK
AD  - Department of Immunology, Genentech, South San Francisco, CA 94080, USA.
FAU - Trifari, Sara
AU  - Trifari S
FAU - Kaplan, Charles D
AU  - Kaplan CD
FAU - Satoh-Takayama, Naoko
AU  - Satoh-Takayama N
FAU - Di Santo, James P
AU  - Di Santo JP
FAU - Spits, Hergen
AU  - Spits H
LA  - eng
PT  - Journal Article
DEP - 20101104
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-7 Receptor alpha Subunit)
RN  - 0 (NF-kappa B)
RN  - 0 (TLR2 protein, human)
RN  - 0 (Toll-Like Receptor 2)
SB  - IM
MH  - Animals
MH  - Autocrine Communication/immunology
MH  - Cells, Cultured
MH  - Cytokines/*metabolism
MH  - Humans
MH  - Interleukin-7 Receptor alpha Subunit/immunology
MH  - Lymphocytes/*immunology
MH  - Mice
MH  - NF-kappa B/immunology
MH  - Palatine Tonsil/immunology
MH  - T-Lymphocytes, Helper-Inducer/*immunology
MH  - Toll-Like Receptor 2/*immunology
EDAT- 2010/11/09 06:00
MHDA- 2010/12/31 06:00
CRDT- 2010/11/09 06:00
PHST- 2009/10/15 00:00 [received]
PHST- 2010/06/08 00:00 [revised]
PHST- 2010/10/08 00:00 [accepted]
PHST- 2010/11/09 06:00 [entrez]
PHST- 2010/11/09 06:00 [pubmed]
PHST- 2010/12/31 06:00 [medline]
AID - S1074-7613(10)00372-9 [pii]
AID - 10.1016/j.immuni.2010.10.012 [doi]
PST - ppublish
SO  - Immunity. 2010 Nov 24;33(5):752-64. doi: 10.1016/j.immuni.2010.10.012. Epub 2010 
      Nov 4.