PMID- 21061430
OWN - NLM
STAT- MEDLINE
DCOM- 20101217
LR  - 20220408
IS  - 1521-4141 (Electronic)
IS  - 0014-2980 (Print)
IS  - 0014-2980 (Linking)
VI  - 40
IP  - 11
DP  - 2010 Nov
TI  - The biology of myeloid-derived suppressor cells: the blessing and the curse of 
      morphological and functional heterogeneity.
PG  - 2969-75
LID - 10.1002/eji.201040895 [doi]
AB  - Myeloid-derived suppressor cells (MDSC) play an important role in the cellular 
      network regulating immune responses in cancer, chronic infectious diseases, 
      autoimmunity, and in other pathological conditions. Morphological, phenotypic and 
      functional heterogeneity is a hallmark of MDSC. This heterogeneity demonstrates 
      the plasticity of this immune suppressive myeloid compartment, and shows how 
      various tumors and infectious agents can have similar biological effects on 
      myeloid cells despite the differences in the factors that they produce to 
      influence the immune system; however, such a heterogeneity creates ambiguity in 
      the definition of MDSC as well as confusion regarding the origin and fate of 
      these cells. In this review, we will discuss recent findings that help to better 
      clarify these issues and to determine the place of MDSC within the myeloid cell 
      lineage.
CI  - Copyright (c) 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Youn, Je-In
AU  - Youn JI
AD  - H. Lee Moffitt Cancer Center, Tampa, FL, USA.
FAU - Gabrilovich, Dmitry I
AU  - Gabrilovich DI
LA  - eng
GR  - R01 CA141438-03/CA/NCI NIH HHS/United States
GR  - R01 CA141438/CA/NCI NIH HHS/United States
GR  - R01 CA084488/CA/NCI NIH HHS/United States
GR  - R01 CA084488-14/CA/NCI NIH HHS/United States
GR  - R01 CA100062-09/CA/NCI NIH HHS/United States
GR  - CA100062/CA/NCI NIH HHS/United States
GR  - R01 CA100062/CA/NCI NIH HHS/United States
GR  - CA84488/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - Germany
TA  - Eur J Immunol
JT  - European journal of immunology
JID - 1273201
SB  - IM
MH  - Animals
MH  - Humans
MH  - Infections/immunology/pathology
MH  - Myeloid Cells/*cytology/*immunology
MH  - Neoplasms/immunology/pathology
PMC - PMC3277452
MID - NIHMS354073
EDAT- 2010/11/10 06:00
MHDA- 2010/12/18 06:00
PMCR- 2012/02/10
CRDT- 2010/11/10 06:00
PHST- 2010/11/10 06:00 [entrez]
PHST- 2010/11/10 06:00 [pubmed]
PHST- 2010/12/18 06:00 [medline]
PHST- 2012/02/10 00:00 [pmc-release]
AID - 10.1002/eji.201040895 [doi]
PST - ppublish
SO  - Eur J Immunol. 2010 Nov;40(11):2969-75. doi: 10.1002/eji.201040895.