PMID- 21074052
OWN - NLM
STAT- MEDLINE
DCOM- 20101208
LR  - 20220317
IS  - 1097-4172 (Electronic)
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 143
IP  - 4
DP  - 2010 Nov 12
TI  - A genome-wide Drosophila screen for heat nociception identifies alpha2delta3 as an 
      evolutionarily conserved pain gene.
PG  - 628-38
LID - 10.1016/j.cell.2010.09.047 [doi]
AB  - Worldwide, acute, and chronic pain affects 20% of the adult population and 
      represents an enormous financial and emotional burden. Using genome-wide 
      neuronal-specific RNAi knockdown in Drosophila, we report a global screen for an 
      innate behavior and identify hundreds of genes implicated in heat nociception, 
      including the alpha2delta family calcium channel subunit straightjacket (stj). Mice 
      mutant for the stj ortholog CACNA2D3 (alpha2delta3) also exhibit impaired behavioral heat 
      pain sensitivity. In addition, in humans, alpha2delta3 SNP variants associate with 
      reduced sensitivity to acute noxious heat and chronic back pain. Functional 
      imaging in alpha2delta3 mutant mice revealed impaired transmission of thermal pain-evoked 
      signals from the thalamus to higher-order pain centers. Intriguingly, in alpha2delta3 
      mutant mice, thermal pain and tactile stimulation triggered strong 
      cross-activation, or synesthesia, of brain regions involved in vision, olfaction, 
      and hearing.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Neely, G Gregory
AU  - Neely GG
AD  - Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr. 
      Bohr Gasse 3-5, A-1030 Vienna, Austria.
FAU - Hess, Andreas
AU  - Hess A
FAU - Costigan, Michael
AU  - Costigan M
FAU - Keene, Alex C
AU  - Keene AC
FAU - Goulas, Spyros
AU  - Goulas S
FAU - Langeslag, Michiel
AU  - Langeslag M
FAU - Griffin, Robert S
AU  - Griffin RS
FAU - Belfer, Inna
AU  - Belfer I
FAU - Dai, Feng
AU  - Dai F
FAU - Smith, Shad B
AU  - Smith SB
FAU - Diatchenko, Luda
AU  - Diatchenko L
FAU - Gupta, Vaijayanti
AU  - Gupta V
FAU - Xia, Cui-Ping
AU  - Xia CP
FAU - Amann, Sabina
AU  - Amann S
FAU - Kreitz, Silke
AU  - Kreitz S
FAU - Heindl-Erdmann, Cornelia
AU  - Heindl-Erdmann C
FAU - Wolz, Susanne
AU  - Wolz S
FAU - Ly, Cindy V
AU  - Ly CV
FAU - Arora, Suchir
AU  - Arora S
FAU - Sarangi, Rinku
AU  - Sarangi R
FAU - Dan, Debasis
AU  - Dan D
FAU - Novatchkova, Maria
AU  - Novatchkova M
FAU - Rosenzweig, Mark
AU  - Rosenzweig M
FAU - Gibson, Dustin G
AU  - Gibson DG
FAU - Truong, Darwin
AU  - Truong D
FAU - Schramek, Daniel
AU  - Schramek D
FAU - Zoranovic, Tamara
AU  - Zoranovic T
FAU - Cronin, Shane J F
AU  - Cronin SJ
FAU - Angjeli, Belinda
AU  - Angjeli B
FAU - Brune, Kay
AU  - Brune K
FAU - Dietzl, Georg
AU  - Dietzl G
FAU - Maixner, William
AU  - Maixner W
FAU - Meixner, Arabella
AU  - Meixner A
FAU - Thomas, Winston
AU  - Thomas W
FAU - Pospisilik, J Andrew
AU  - Pospisilik JA
FAU - Alenius, Mattias
AU  - Alenius M
FAU - Kress, Michaela
AU  - Kress M
FAU - Subramaniam, Sai
AU  - Subramaniam S
FAU - Garrity, Paul A
AU  - Garrity PA
FAU - Bellen, Hugo J
AU  - Bellen HJ
FAU - Woolf, Clifford J
AU  - Woolf CJ
FAU - Penninger, Josef M
AU  - Penninger JM
LA  - eng
GR  - R01 NS039518-09/NS/NINDS NIH HHS/United States
GR  - R01 NS039518/NS/NINDS NIH HHS/United States
GR  - R37 NS039518/NS/NINDS NIH HHS/United States
GR  - P01 NS044232/NS/NINDS NIH HHS/United States
GR  - F32 GM086207-02/GM/NIGMS NIH HHS/United States
GR  - R01 NS038253/NS/NINDS NIH HHS/United States
GR  - F32 GM086207/GM/NIGMS NIH HHS/United States
GR  - P01 NS072040/NS/NINDS NIH HHS/United States
GR  - R01 NS058870-04/NS/NINDS NIH HHS/United States
GR  - R01 NS058870/NS/NINDS NIH HHS/United States
GR  - R01 NS038253-12/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (CACNA2D3 protein, human)
RN  - 0 (CACNA2D3 protein, mouse)
RN  - 0 (Calcium Channels)
RN  - 0 (Drosophila Proteins)
RN  - 0 (stj protein, Drosophila)
SB  - IM
CIN - Cell. 2010 Nov 12;143(4):505-7. PMID: 21074043
MH  - Adult
MH  - Animals
MH  - Back Pain/genetics
MH  - Calcium Channels/*genetics/metabolism
MH  - Drosophila/*genetics
MH  - Drosophila Proteins/*genetics/metabolism
MH  - Gene Knockdown Techniques
MH  - Genome-Wide Association Study
MH  - Hot Temperature
MH  - Humans
MH  - Mice
MH  - Pain/*genetics
MH  - Polymorphism, Single Nucleotide
MH  - RNA Interference
PMC - PMC3040441
MID - NIHMS244454
EDAT- 2010/11/16 06:00
MHDA- 2010/12/14 06:00
PMCR- 2011/11/12
CRDT- 2010/11/16 06:00
PHST- 2010/03/08 00:00 [received]
PHST- 2010/08/09 00:00 [revised]
PHST- 2010/09/24 00:00 [accepted]
PHST- 2010/11/16 06:00 [entrez]
PHST- 2010/11/16 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PHST- 2011/11/12 00:00 [pmc-release]
AID - S0092-8674(10)01133-5 [pii]
AID - 10.1016/j.cell.2010.09.047 [doi]
PST - ppublish
SO  - Cell. 2010 Nov 12;143(4):628-38. doi: 10.1016/j.cell.2010.09.047.