PMID- 21075313
OWN - NLM
STAT- MEDLINE
DCOM- 20101216
LR  - 20230425
IS  - 1878-3686 (Electronic)
IS  - 1535-6108 (Print)
IS  - 1535-6108 (Linking)
VI  - 18
IP  - 5
DP  - 2010 Nov 16
TI  - Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is 
      reversible and not hierarchically organized.
PG  - 510-23
LID - 10.1016/j.ccr.2010.10.012 [doi]
AB  - We investigated whether melanoma is hierarchically organized into phenotypically 
      distinct subpopulations of tumorigenic and nontumorigenic cells or whether most 
      melanoma cells retain tumorigenic capacity, irrespective of their phenotype. We 
      found 28% of single melanoma cells obtained directly from patients formed tumors 
      in NOD/SCID IL2Rgamma(null) mice. All stage II, III, and IV melanomas obtained 
      directly from patients had common tumorigenic cells. All tumorigenic cells 
      appeared to have unlimited tumorigenic capacity on serial transplantation. We 
      were unable to find any large subpopulation of melanoma cells that lacked 
      tumorigenic potential. None of 22 heterogeneously expressed markers, including 
      CD271 and ABCB5, enriched tumorigenic cells. Some melanomas metastasized in mice, 
      irrespective of whether they arose from CD271(-) or CD271(+) cells. Many markers 
      appeared to be reversibly expressed by tumorigenic melanoma cells.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Quintana, Elsa
AU  - Quintana E
AD  - Howard Hughes Medical Institute.
FAU - Shackleton, Mark
AU  - Shackleton M
FAU - Foster, Hannah R
AU  - Foster HR
FAU - Fullen, Douglas R
AU  - Fullen DR
FAU - Sabel, Michael S
AU  - Sabel MS
FAU - Johnson, Timothy M
AU  - Johnson TM
FAU - Morrison, Sean J
AU  - Morrison SJ
LA  - eng
GR  - HHMI/Howard Hughes Medical Institute/United States
GR  - P30 CA046592/CA/NCI NIH HHS/United States
GR  - CA46592/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Cell
JT  - Cancer cell
JID - 101130617
RN  - 0 (ABCB5 protein, human)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 1)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Naphthalenes)
RN  - 1L4806J2QF (Adapalene)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily B
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism
MH  - Adapalene
MH  - Animals
MH  - Biomarkers, Tumor/metabolism
MH  - Cell Proliferation
MH  - Humans
MH  - Melanoma/metabolism/*pathology
MH  - Mice
MH  - Mice, Inbred NOD
MH  - Mice, SCID
MH  - Naphthalenes/metabolism
MH  - Neoplasm Metastasis
MH  - *Phenotype
MH  - Transplantation, Heterologous/pathology
PMC - PMC3031091
MID - NIHMS254638
OID - NLM: HHMIMS254638
EDAT- 2010/11/16 06:00
MHDA- 2010/12/17 06:00
PMCR- 2011/05/16
CRDT- 2010/11/16 06:00
PHST- 2010/06/02 00:00 [received]
PHST- 2010/09/11 00:00 [revised]
PHST- 2010/10/12 00:00 [accepted]
PHST- 2010/11/16 06:00 [entrez]
PHST- 2010/11/16 06:00 [pubmed]
PHST- 2010/12/17 06:00 [medline]
PHST- 2011/05/16 00:00 [pmc-release]
AID - S1535-6108(10)00416-2 [pii]
AID - 10.1016/j.ccr.2010.10.012 [doi]
PST - ppublish
SO  - Cancer Cell. 2010 Nov 16;18(5):510-23. doi: 10.1016/j.ccr.2010.10.012.