PMID- 21078993
OWN - NLM
STAT- MEDLINE
DCOM- 20110131
LR  - 20211203
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 107
IP  - 49
DP  - 2010 Dec 7
TI  - Hippo signaling regulates Drosophila intestine stem cell proliferation through 
      multiple pathways.
PG  - 21064-9
LID - 10.1073/pnas.1012759107 [doi]
AB  - Intestinal stem cells (ISCs) in the Drosophila adult midgut are essential for 
      maintaining tissue homeostasis and replenishing lost cells in response to tissue 
      damage. Here we demonstrate that the Hippo (Hpo) signaling pathway, an 
      evolutionarily conserved pathway implicated in organ size control and 
      tumorigenesis, plays an essential role in regulating ISC proliferation. Loss of 
      Hpo signaling in either midgut precursor cells or epithelial cells stimulates ISC 
      proliferation. We provide evidence that loss of Hpo signaling in epithelial cells 
      increases the production of cytokines of the Upd family and multiple EGFR ligands 
      that activate JAK-STAT and EGFR signaling pathways in ISCs to stimulate their 
      proliferation, thus revealing a unique non-cell-autonomous role of Hpo signaling 
      in blocking ISC proliferation. Finally, we show that the Hpo pathway mediator 
      Yorkie (Yki) is also required in precursor cells for injury-induced ISC 
      proliferation in response to tissue-damaging reagent DSS.
FAU - Ren, Fangfang
AU  - Ren F
AD  - Department of Developmental Biology, University of Texas Southwestern Medical 
      Center, Dallas, TX 75390, USA.
FAU - Wang, Bing
AU  - Wang B
FAU - Yue, Tao
AU  - Yue T
FAU - Yun, Eun-Young
AU  - Yun EY
FAU - Ip, Y Tony
AU  - Ip YT
FAU - Jiang, Jin
AU  - Jiang J
LA  - eng
GR  - R01 GM067045/GM/NIGMS NIH HHS/United States
GR  - P30 DK032520/DK/NIDDK NIH HHS/United States
GR  - DK32520/DK/NIDDK NIH HHS/United States
GR  - R01 DK083450/DK/NIDDK NIH HHS/United States
GR  - R21 DK075545/DK/NIDDK NIH HHS/United States
GR  - R01DK83450/DK/NIDDK NIH HHS/United States
GR  - R01 GM061269/GM/NIGMS NIH HHS/United States
GR  - R01 DK083450-01A1/DK/NIDDK NIH HHS/United States
GR  - GM061269/GM/NIGMS NIH HHS/United States
GR  - R21DK75545/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20101115
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Cytokines)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Receptors, Invertebrate Peptide)
RN  - 0 (Trans-Activators)
RN  - 0 (YAP-Signaling Proteins)
RN  - 0 (Yki protein, Drosophila)
RN  - EC 2.7.10.1 (Egfr protein, Drosophila)
RN  - EC 2.7.10.1 (ErbB Receptors)
RN  - EC 2.7.10.2 (Janus Kinases)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (hpo protein, Drosophila)
SB  - IM
MH  - Animals
MH  - *Cell Proliferation
MH  - Cytokines/biosynthesis
MH  - Drosophila Proteins/metabolism/*physiology
MH  - Epithelial Cells
MH  - ErbB Receptors/metabolism
MH  - Intestines/*cytology
MH  - Intracellular Signaling Peptides and Proteins/*physiology
MH  - Janus Kinases/metabolism
MH  - Nuclear Proteins
MH  - Protein Serine-Threonine Kinases/*physiology
MH  - Receptors, Invertebrate Peptide/metabolism
MH  - Signal Transduction/*physiology
MH  - Stem Cells/*physiology
MH  - Trans-Activators
MH  - YAP-Signaling Proteins
PMC - PMC3000252
COIS- The authors declare no conflict of interest.
EDAT- 2010/11/17 06:00
MHDA- 2011/02/01 06:00
PMCR- 2011/06/07
CRDT- 2010/11/17 06:00
PHST- 2010/11/17 06:00 [entrez]
PHST- 2010/11/17 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
PHST- 2011/06/07 00:00 [pmc-release]
AID - 1012759107 [pii]
AID - 201012759 [pii]
AID - 10.1073/pnas.1012759107 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21064-9. doi: 
      10.1073/pnas.1012759107. Epub 2010 Nov 15.