PMID- 21088215
OWN - NLM
STAT- MEDLINE
DCOM- 20110315
LR  - 20211020
IS  - 1525-2191 (Electronic)
IS  - 0002-9440 (Print)
IS  - 0002-9440 (Linking)
VI  - 177
IP  - 6
DP  - 2010 Dec
TI  - Links between progressive HIV-1 infection of humanized mice and viral 
      neuropathogenesis.
PG  - 2938-49
LID - 10.2353/ajpath.2010.100536 [doi]
AB  - Few rodent models of human immunodeficiency virus type one (HIV-1) infection can 
      reflect the course of viral infection in humans. To this end, we investigated the 
      relationships between progressive HIV-1 infection, immune compromise, and 
      neuroinflammatory responses in NOD/scid-IL-2Rgamma(c)(null) mice reconstituted with 
      human hematopoietic CD34(+) stem cells. Human blood-borne macrophages repopulated 
      the meninges and perivascular spaces of chimeric animals. Viral infection in 
      lymphoid tissue led to the accelerated entry of human cells into the brain, 
      marked neuroinflammation, and HIV-1 replication in human mononuclear phagocytes. 
      A meningitis and less commonly an encephalitis followed cM-T807 antibody-mediated 
      CD8(+) cell depletion. We conclude that HIV-1-infected NOD/scid-IL-2Rgamma(c)(null) 
      humanized mice can, at least in part, recapitulate lentiviral neuropathobiology. 
      This model of neuroAIDS reflects the virological, immunological, and early 
      disease-associated neuropathological components of human disease.
FAU - Gorantla, Santhi
AU  - Gorantla S
AD  - Department of Pharmacology and Experimental Neuroscience, University of Nebraska 
      Medical Center, Omaha, NE 68198-5880, USA.
FAU - Makarov, Edward
AU  - Makarov E
FAU - Finke-Dwyer, Jennifer
AU  - Finke-Dwyer J
FAU - Castanedo, Antonio
AU  - Castanedo A
FAU - Holguin, Adelina
AU  - Holguin A
FAU - Gebhart, Catherine L
AU  - Gebhart CL
FAU - Gendelman, Howard E
AU  - Gendelman HE
FAU - Poluektova, Larisa
AU  - Poluektova L
LA  - eng
GR  - R01 NS036126/NS/NINDS NIH HHS/United States
GR  - P01MH64570/MH/NIMH NIH HHS/United States
GR  - P01 NS031492/NS/NINDS NIH HHS/United States
GR  - P01 NS31492/NS/NINDS NIH HHS/United States
GR  - P30 AI042845/AI/NIAID NIH HHS/United States
GR  - P01 DA026146/DA/NIDA NIH HHS/United States
GR  - R21 NS060642-02/NS/NINDS NIH HHS/United States
GR  - 2R01 NS034239/NS/NINDS NIH HHS/United States
GR  - R21 NS060642-01/NS/NINDS NIH HHS/United States
GR  - P01 MH064570/MH/NIMH NIH HHS/United States
GR  - R01 MH083516/MH/NIMH NIH HHS/United States
GR  - R21 NS060642/NS/NINDS NIH HHS/United States
GR  - R01 NS034239/NS/NINDS NIH HHS/United States
GR  - 1 R01MH083516/MH/NIMH NIH HHS/United States
GR  - P01 NS043985-01A1/NS/NINDS NIH HHS/United States
GR  - P30 AI42845/AI/NIAID NIH HHS/United States
GR  - 1P01DA028555-01/DA/NIDA NIH HHS/United States
GR  - P01 NS043985/NS/NINDS NIH HHS/United States
GR  - P01 DA028555/DA/NIDA NIH HHS/United States
GR  - R21NS060642-01/NS/NINDS NIH HHS/United States
GR  - 1 P01 NS043985-01/NS/NINDS NIH HHS/United States
GR  - 5R01 NS36126/NS/NINDS NIH HHS/United States
GR  - P20DA026146/DA/NIDA NIH HHS/United States
GR  - P20 RR015635/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20101118
PL  - United States
TA  - Am J Pathol
JT  - The American journal of pathology
JID - 0370502
RN  - 0 (Il2rg protein, mouse)
RN  - 0 (Interleukin Receptor Common gamma Subunit)
SB  - IM
MH  - AIDS Dementia Complex/*etiology/pathology/virology
MH  - Animals
MH  - Brain/immunology/virology
MH  - Cells, Cultured
MH  - *Disease Models, Animal
MH  - Disease Progression
MH  - HIV Infections/*complications/immunology/pathology/virology
MH  - HIV-1/*physiology
MH  - Humans
MH  - Interleukin Receptor Common gamma Subunit/genetics
MH  - Meningitis, Viral/complications
MH  - *Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred NOD
MH  - Mice, SCID
MH  - Mice, Transgenic
PMC - PMC2993281
EDAT- 2010/11/23 06:00
MHDA- 2011/03/16 06:00
PMCR- 2011/12/01
CRDT- 2010/11/20 06:00
PHST- 2010/11/20 06:00 [entrez]
PHST- 2010/11/23 06:00 [pubmed]
PHST- 2011/03/16 06:00 [medline]
PHST- 2011/12/01 00:00 [pmc-release]
AID - S0002-9440(10)62920-3 [pii]
AID - 10.2353/ajpath.2010.100536 [doi]
PST - ppublish
SO  - Am J Pathol. 2010 Dec;177(6):2938-49. doi: 10.2353/ajpath.2010.100536. Epub 2010 
      Nov 18.