PMID- 21093587
OWN - NLM
STAT- MEDLINE
DCOM- 20110714
LR  - 20220410
IS  - 1873-3441 (Electronic)
IS  - 0939-6411 (Print)
IS  - 0939-6411 (Linking)
VI  - 77
IP  - 3
DP  - 2011 Apr
TI  - Geometry and surface characteristics of gold nanoparticles influence their 
      biodistribution and uptake by macrophages.
PG  - 417-23
LID - 10.1016/j.ejpb.2010.11.010 [doi]
AB  - Spherical and rod-shaped gold nanoparticles with surface poly(ethylene glycol) 
      (PEG) chains were characterized for size, shape, charge, poly dispersity and 
      surface plasmon resonance. The nanoparticles were injected intravenously to 
      6-8-week-old female nu/nu mice bearing orthotopic ovarian tumors, and their 
      biodistribution in vital organs was compared. Gold nanorods were taken up to a 
      lesser extent by the liver, had longer circulation time in the blood, and higher 
      accumulation in the tumors, compared with their spherical counterparts. The 
      cellular uptake of PEGylated gold nanoparticles by a murine macrophage-like cell 
      line as a function of geometry was examined. Compared to nanospheres, PEGylated 
      gold nanorods were taken up to a lesser extent by macrophages. These studies 
      point to the importance of gold nanoparticle geometry and surface properties on 
      transport across biological barriers.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Arnida
AU  - Arnida
AD  - Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 
      Salt Lake City, UT 84108, USA.
FAU - Janat-Amsbury, M M
AU  - Janat-Amsbury MM
FAU - Ray, A
AU  - Ray A
FAU - Peterson, C M
AU  - Peterson CM
FAU - Ghandehari, H
AU  - Ghandehari H
LA  - eng
GR  - R01 DE019050-05/DE/NIDCR NIH HHS/United States
GR  - R01 DE019050-01/DE/NIDCR NIH HHS/United States
GR  - R01 DE019050-02/DE/NIDCR NIH HHS/United States
GR  - R01 DE019050-03/DE/NIDCR NIH HHS/United States
GR  - R01/PHS HHS/United States
GR  - R01 DE019050-04/DE/NIDCR NIH HHS/United States
GR  - R01 DE019050/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20101118
PL  - Netherlands
TA  - Eur J Pharm Biopharm
JT  - European journal of pharmaceutics and biopharmaceutics : official journal of 
      Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
JID - 9109778
RN  - 27432CM55Q (Serum Albumin, Bovine)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 7440-57-5 (Gold)
SB  - IM
MH  - Animals
MH  - Biological Transport
MH  - Cell Line
MH  - Female
MH  - *Gold
MH  - Injections, Intravenous
MH  - Macrophages/*metabolism
MH  - Metal Nanoparticles/*administration & dosage/chemistry
MH  - Mice
MH  - Mice, Nude
MH  - Microscopy, Electron, Transmission
MH  - Nanotubes/chemistry
MH  - Ovarian Neoplasms/metabolism
MH  - Particle Size
MH  - Polyethylene Glycols/chemistry
MH  - Protein Binding
MH  - Serum Albumin, Bovine/chemistry
MH  - Surface Properties
MH  - Tissue Distribution
PMC - PMC3379889
MID - NIHMS259353
EDAT- 2010/11/26 06:00
MHDA- 2011/07/16 06:00
PMCR- 2012/06/20
CRDT- 2010/11/25 06:00
PHST- 2010/09/01 00:00 [received]
PHST- 2010/11/09 00:00 [revised]
PHST- 2010/11/11 00:00 [accepted]
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
PHST- 2012/06/20 00:00 [pmc-release]
AID - S0939-6411(10)00299-7 [pii]
AID - 10.1016/j.ejpb.2010.11.010 [doi]
PST - ppublish
SO  - Eur J Pharm Biopharm. 2011 Apr;77(3):417-23. doi: 10.1016/j.ejpb.2010.11.010. 
      Epub 2010 Nov 18.