PMID- 21102585
OWN - NLM
STAT- MEDLINE
DCOM- 20110215
LR  - 20220318
IS  - 1532-1827 (Electronic)
IS  - 0007-0920 (Print)
IS  - 0007-0920 (Linking)
VI  - 104
IP  - 1
DP  - 2011 Jan 4
TI  - Mst1/2 signalling to Yap: gatekeeper for liver size and tumour development.
PG  - 24-32
LID - 10.1038/sj.bjc.6606011 [doi]
AB  - The mechanisms controlling mammalian organ size have long been a source of 
      fascination for biologists. These controls are needed to both ensure the 
      integrity of the body plan and to restrict inappropriate proliferation that could 
      lead to cancer. Regulation of liver size is of particular interest inasmuch as 
      this organ maintains the capacity for regeneration throughout life, and is able 
      to regain precisely its original mass after partial surgical resection. Recent 
      studies using genetically engineered mouse strains have shed new light on this 
      problem; the Hippo signalling pathway, first elucidated as a regulator of organ 
      size in Drosophila, has been identified as dominant determinant of liver growth. 
      Defects in this pathway in mouse liver lead to sustained liver overgrowth and the 
      eventual development of both major types of liver cancer, hepatocellular 
      carcinoma and cholangiocarcinoma. In this review, we discuss the role of Hippo 
      signalling in liver biology and the contribution of this pathway to liver cancer 
      in humans.
FAU - Avruch, J
AU  - Avruch J
AD  - Department of Molecular Biology, Massachusetts General Hospital, Simches Research 
      Building, 6408, 185 Cambridge Street, Boston, MA 02115, USA. 
      avruch@molbio.mgh.harvard.edu
FAU - Zhou, D
AU  - Zhou D
FAU - Fitamant, J
AU  - Fitamant J
FAU - Bardeesy, N
AU  - Bardeesy N
LA  - eng
GR  - T32DK007028/DK/NIDDK NIH HHS/United States
GR  - DK17776/DK/NIDDK NIH HHS/United States
GR  - T32 DK007028/DK/NIDDK NIH HHS/United States
GR  - CA136567/CA/NCI NIH HHS/United States
GR  - R01 CA136567/CA/NCI NIH HHS/United States
GR  - R37 DK017776/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20101123
PL  - England
TA  - Br J Cancer
JT  - British journal of cancer
JID - 0370635
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Phosphoproteins)
RN  - 0 (Transcription Factors)
RN  - 0 (YAP-Signaling Proteins)
RN  - 0 (YY1AP1 protein, human)
RN  - 0 (Yap1 protein, mouse)
RN  - EC 2.7.1.- (Stk4 protein, mouse)
RN  - EC 2.7.1.11 (STK4 protein, human)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (STK3 protein, human)
RN  - EC 2.7.11.1 (Serine-Threonine Kinase 3)
RN  - EC 2.7.11.1 (Stk3 protein, mouse)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing/physiology
MH  - Animals
MH  - Cell Cycle Proteins
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins
MH  - Liver Neoplasms/enzymology/*pathology
MH  - Mice
MH  - Nuclear Proteins/*physiology
MH  - Organ Size
MH  - Phosphoproteins/physiology
MH  - Protein Serine-Threonine Kinases/*physiology
MH  - Serine-Threonine Kinase 3
MH  - *Signal Transduction
MH  - Transcription Factors/*physiology
MH  - YAP-Signaling Proteins
PMC - PMC3039822
EDAT- 2010/11/26 06:00
MHDA- 2011/02/16 06:00
PMCR- 2012/01/04
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/02/16 06:00 [medline]
PHST- 2012/01/04 00:00 [pmc-release]
AID - 6606011 [pii]
AID - 10.1038/sj.bjc.6606011 [doi]
PST - ppublish
SO  - Br J Cancer. 2011 Jan 4;104(1):24-32. doi: 10.1038/sj.bjc.6606011. Epub 2010 Nov 
      23.