PMID- 21128716
OWN - NLM
STAT- MEDLINE
DCOM- 20110328
LR  - 20220309
IS  - 1748-6963 (Electronic)
IS  - 1743-5889 (Print)
IS  - 1743-5889 (Linking)
VI  - 5
IP  - 9
DP  - 2010 Nov
TI  - Intrinsic targeting of inflammatory cells in the brain by polyamidoamine 
      dendrimers upon subarachnoid administration.
PG  - 1317-29
LID - 10.2217/nnm.10.89 [doi]
AB  - AIM: Understanding the interactions between nanomaterials and disease processes 
      is crucial for designing effective therapeutic approaches. This article explores 
      the unusual neuroinflammation targeting of dendrimers (with no targeting ligands) 
      in the brain, with significant consequences for nanoscale materials in medicine. 
      METHOD: The in vivo biodistribution of fluorescent-labeled neutral generation-4- 
      polyamidoamine dendrimers ( approximately 4 nm) in a rabbit model of cerebral palsy was 
      explored following subarachnoid administration. RESULTS: These dendrimers, with 
      no targeting ligands, were localizing in activated microglia and astrocytes 
      (cells responsible for neuroinflammation), even in regions far moved from the 
      site of injection, in newborn rabbits with maternal inflammation-induced cerebral 
      palsy. CONCLUSION: This intrinsic ability of dendrimers to localize inactivated 
      microglia and astrocytes can enable targeted delivery of therapeutics in 
      disorders such as cerebral palsy, Alzheimer's and multiple sclerosis.
FAU - Dai, Hui
AU  - Dai H
AD  - Department of Pediatrics (Critical Care Medicine), Children's Hospital of 
      Michigan, Wayne State University, Detroit, MI 48201, USA.
FAU - Navath, Raghavendra S
AU  - Navath RS
FAU - Balakrishnan, Bindu
AU  - Balakrishnan B
FAU - Guru, Bharath Raja
AU  - Guru BR
FAU - Mishra, Manoj K
AU  - Mishra MK
FAU - Romero, Roberto
AU  - Romero R
FAU - Kannan, Rangaramanujam M
AU  - Kannan RM
FAU - Kannan, Sujatha
AU  - Kannan S
LA  - eng
GR  - K08 HD050652/HD/NICHD NIH HHS/United States
GR  - N01 HD023342/HD/NICHD NIH HHS/United States
GR  - 1K08HD050652/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nanomedicine (Lond)
JT  - Nanomedicine (London, England)
JID - 101278111
RN  - 0 (Dendrimers)
RN  - 0 (PAMAM Starburst)
RN  - I223NX31W9 (Fluorescein-5-isothiocyanate)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Astrocytes/*metabolism
MH  - Brain/*metabolism
MH  - Cerebral Palsy/metabolism
MH  - Chromatography, High Pressure Liquid
MH  - Dendrimers/*administration & dosage/chemistry/*metabolism
MH  - Female
MH  - Fluorescein-5-isothiocyanate/chemistry
MH  - Male
MH  - Microglia/*metabolism
MH  - Rabbits
MH  - Subarachnoid Space/*metabolism
PMC - PMC3095441
MID - NIHMS268541
COIS- Financial & competing interests disclosure The authors have no other relevant 
      affiliations or financial involvement with any organization or entity with a 
      financial interest in or financial conflict with the subject matter or materials 
      discussed in the manuscript apart from those disclosed. No writing assistance was 
      utilized in the production of this manuscript.
EDAT- 2010/12/07 06:00
MHDA- 2011/03/29 06:00
PMCR- 2011/09/01
CRDT- 2010/12/07 06:00
PHST- 2010/12/07 06:00 [entrez]
PHST- 2010/12/07 06:00 [pubmed]
PHST- 2011/03/29 06:00 [medline]
PHST- 2011/09/01 00:00 [pmc-release]
AID - 10.2217/nnm.10.89 [doi]
PST - ppublish
SO  - Nanomedicine (Lond). 2010 Nov;5(9):1317-29. doi: 10.2217/nnm.10.89.