PMID- 21129968
OWN - NLM
STAT- MEDLINE
DCOM- 20110516
LR  - 20110110
IS  - 1879-0445 (Electronic)
IS  - 0960-9822 (Linking)
VI  - 21
IP  - 1
DP  - 2011 Jan 11
TI  - Three-dimensional reconstruction of brain-wide wiring networks in Drosophila at 
      single-cell resolution.
PG  - 1-11
LID - 10.1016/j.cub.2010.11.056 [doi]
AB  - BACKGROUND: Animal behavior is governed by the activity of interconnected brain 
      circuits. Comprehensive brain wiring maps are thus needed in order to formulate 
      hypotheses about information flow and also to guide genetic manipulations aimed 
      at understanding how genes and circuits orchestrate complex behaviors. RESULTS: 
      To assemble this map, we deconstructed the adult Drosophila brain into 
      approximately 16,000 single neurons and reconstructed them into a common 
      standardized framework to produce a virtual fly brain. We have constructed a 
      mesoscopic map and found that it consists of 41 local processing units (LPUs), 
      six hubs, and 58 tracts covering the whole Drosophila brain. Despite individual 
      local variation, the architecture of the Drosophila brain shows invariance for 
      both the aggregation of local neurons (LNs) within specific LPUs and for the 
      connectivity of projection neurons (PNs) between the same set of LPUs. An 
      open-access image database, named FlyCircuit, has been constructed for online 
      data archiving, mining, analysis, and three-dimensional visualization of all 
      single neurons, brain-wide LPUs, their wiring diagrams, and neural tracts. 
      CONCLUSION: We found that the Drosophila brain is assembled from families of 
      multiple LPUs and their interconnections. This provides an essential first step 
      in the analysis of information processing within and between neurons in a 
      complete brain.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Chiang, Ann-Shyn
AU  - Chiang AS
AD  - Brain Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan, 
      R.O.C. aschiang@life.nthu.edu.tw
FAU - Lin, Chih-Yung
AU  - Lin CY
FAU - Chuang, Chao-Chun
AU  - Chuang CC
FAU - Chang, Hsiu-Ming
AU  - Chang HM
FAU - Hsieh, Chang-Huain
AU  - Hsieh CH
FAU - Yeh, Chang-Wei
AU  - Yeh CW
FAU - Shih, Chi-Tin
AU  - Shih CT
FAU - Wu, Jian-Jheng
AU  - Wu JJ
FAU - Wang, Guo-Tzau
AU  - Wang GT
FAU - Chen, Yung-Chang
AU  - Chen YC
FAU - Wu, Cheng-Chi
AU  - Wu CC
FAU - Chen, Guan-Yu
AU  - Chen GY
FAU - Ching, Yu-Tai
AU  - Ching YT
FAU - Lee, Ping-Chang
AU  - Lee PC
FAU - Lin, Chih-Yang
AU  - Lin CY
FAU - Lin, Hui-Hao
AU  - Lin HH
FAU - Wu, Chia-Chou
AU  - Wu CC
FAU - Hsu, Hao-Wei
AU  - Hsu HW
FAU - Huang, Yun-Ann
AU  - Huang YA
FAU - Chen, Jing-Yi
AU  - Chen JY
FAU - Chiang, Hsin-Jung
AU  - Chiang HJ
FAU - Lu, Chun-Fang
AU  - Lu CF
FAU - Ni, Ru-Fen
AU  - Ni RF
FAU - Yeh, Chao-Yuan
AU  - Yeh CY
FAU - Hwang, Jenn-Kang
AU  - Hwang JK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101202
PL  - England
TA  - Curr Biol
JT  - Current biology : CB
JID - 9107782
SB  - IM
CIN - Curr Biol. 2011 Jan 11;21(1):R19-20. PMID: 21215929
MH  - Animals
MH  - Brain/*cytology/physiology
MH  - Computer Simulation
MH  - Drosophila/*anatomy & histology/*physiology
MH  - Female
MH  - Male
MH  - Models, Biological
MH  - Neurons/cytology/physiology
EDAT- 2010/12/07 06:00
MHDA- 2011/05/17 06:00
CRDT- 2010/12/07 06:00
PHST- 2010/10/11 00:00 [received]
PHST- 2010/11/05 00:00 [revised]
PHST- 2010/11/22 00:00 [accepted]
PHST- 2010/12/07 06:00 [entrez]
PHST- 2010/12/07 06:00 [pubmed]
PHST- 2011/05/17 06:00 [medline]
AID - S0960-9822(10)01522-8 [pii]
AID - 10.1016/j.cub.2010.11.056 [doi]
PST - ppublish
SO  - Curr Biol. 2011 Jan 11;21(1):1-11. doi: 10.1016/j.cub.2010.11.056. Epub 2010 Dec 
      2.