PMID- 21160525
OWN - NLM
STAT- MEDLINE
DCOM- 20110201
LR  - 20220410
IS  - 1474-1768 (Electronic)
IS  - 1474-175X (Linking)
VI  - 11
IP  - 1
DP  - 2011 Jan
TI  - The molecular biology of head and neck cancer.
PG  - 9-22
LID - 10.1038/nrc2982 [doi]
AB  - Head and neck squamous cell carcinomas (HNSCCs) are caused by tobacco and alcohol 
      consumption and by infection with high-risk types of human papillomavirus (HPV). 
      Tumours often develop within preneoplastic fields of genetically altered cells. 
      The persistence of these fields after treatment presents a major challenge, 
      because it might lead to local recurrences and second primary tumours that are 
      responsible for a large proportion of deaths. Aberrant signalling pathways have 
      been identified in HNSCCs and inhibition of epidermal growth factor receptor 
      (EGFR) has proved a successful therapeutic strategy. In this Review, we discuss 
      the recent literature on tumour heterogeneity, field cancerization, molecular 
      pathogenesis and the underlying causative cancer genes that can be exploited for 
      novel and personalized treatments of patients with HNSCC.
FAU - Leemans, C Rene
AU  - Leemans CR
AD  - Department of Otolaryngology-Head and Neck Surgery, VU University Medical Center, 
      Amsterdam, The Netherlands. cr.leemans@vumc.nl
FAU - Braakhuis, Boudewijn J M
AU  - Braakhuis BJ
FAU - Brakenhoff, Ruud H
AU  - Brakenhoff RH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20101216
PL  - England
TA  - Nat Rev Cancer
JT  - Nature reviews. Cancer
JID - 101124168
SB  - IM
CIN - Nat Rev Cancer. 2011 May;11(5):382; author reply 382. PMID: 21455256
MH  - Animals
MH  - Head and Neck Neoplasms/*genetics/*pathology
MH  - Humans
MH  - Molecular Biology
EDAT- 2010/12/17 06:00
MHDA- 2011/02/02 06:00
CRDT- 2010/12/17 06:00
PHST- 2010/12/17 06:00 [entrez]
PHST- 2010/12/17 06:00 [pubmed]
PHST- 2011/02/02 06:00 [medline]
AID - nrc2982 [pii]
AID - 10.1038/nrc2982 [doi]
PST - ppublish
SO  - Nat Rev Cancer. 2011 Jan;11(1):9-22. doi: 10.1038/nrc2982. Epub 2010 Dec 16.