PMID- 21167805
OWN - NLM
STAT- MEDLINE
DCOM- 20110615
LR  - 20211020
IS  - 1875-9777 (Electronic)
IS  - 1934-5909 (Print)
IS  - 1875-9777 (Linking)
VI  - 8
IP  - 1
DP  - 2011 Jan 7
TI  - EGFR/Ras/MAPK signaling mediates adult midgut epithelial homeostasis and 
      regeneration in Drosophila.
PG  - 84-95
LID - 10.1016/j.stem.2010.11.026 [doi]
AB  - Many tissues in higher animals undergo dynamic homeostatic growth, wherein 
      damaged or aged cells are replaced by the progeny of resident stem cells. To 
      maintain homeostasis, stem cells must respond to tissue needs. Here we show that 
      in response to damage or stress in the intestinal (midgut) epithelium of adult 
      Drosophila, multiple EGFR ligands and rhomboids (intramembrane proteases that 
      activate some EGFR ligands) are induced, leading to the activation of EGFR 
      signaling in intestinal stem cells (ISCs). Activation of EGFR signaling promotes 
      ISC division and midgut epithelium regeneration, thereby maintaining tissue 
      homeostasis. ISCs defective in EGFR signaling cannot grow or divide, are poorly 
      maintained, and cannot support midgut epithelium regeneration after enteric 
      infection by the bacterium Pseudomonas entomophila. Furthermore, ISC 
      proliferation induced by Jak/Stat signaling is dependent upon EGFR signaling. 
      Thus the EGFR/Ras/MAPK signaling pathway plays central, essential roles in ISC 
      maintenance and the feedback system that mediates intestinal homeostasis.
CI  - Copyright A(c) 2011 Elsevier Inc. All rights reserved.
FAU - Jiang, Huaqi
AU  - Jiang H
AD  - Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview 
      Avenue N., Seattle, WA 98109, USA.
FAU - Grenley, Marc O
AU  - Grenley MO
FAU - Bravo, Maria-Jose
AU  - Bravo MJ
FAU - Blumhagen, Rachel Z
AU  - Blumhagen RZ
FAU - Edgar, Bruce A
AU  - Edgar BA
LA  - eng
GR  - R01 GM051186/GM/NIGMS NIH HHS/United States
GR  - R01 GM051186-14A1/GM/NIGMS NIH HHS/United States
GR  - R25 HG007153/HG/NHGRI NIH HHS/United States
GR  - R01 GM51186/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20101216
PL  - United States
TA  - Cell Stem Cell
JT  - Cell stem cell
JID - 101311472
RN  - 0 (Drosophila Proteins)
RN  - 0 (Receptors, Invertebrate Peptide)
RN  - EC 2.7.10.1 (Egfr protein, Drosophila)
RN  - EC 2.7.10.1 (ErbB Receptors)
RN  - EC 2.7.10.2 (Janus Kinases)
RN  - EC 3.6.5.2 (ras Proteins)
SB  - IM
MH  - Animals
MH  - Animals, Inbred Strains
MH  - Cell Proliferation
MH  - Drosophila/*physiology
MH  - Drosophila Proteins/*metabolism
MH  - Epithelial Cells/cytology/metabolism
MH  - ErbB Receptors/*metabolism
MH  - Homeostasis
MH  - Intestinal Mucosa/enzymology/metabolism/*physiology
MH  - Janus Kinases/metabolism
MH  - MAP Kinase Signaling System/*physiology
MH  - Receptors, Invertebrate Peptide/*metabolism
MH  - Regeneration/*physiology
MH  - Stem Cells/cytology/enzymology/*metabolism
MH  - ras Proteins/*metabolism
PMC - PMC3021119
MID - NIHMS256143
EDAT- 2010/12/21 06:00
MHDA- 2011/06/16 06:00
PMCR- 2012/01/07
CRDT- 2010/12/21 06:00
PHST- 2010/04/20 00:00 [received]
PHST- 2010/09/20 00:00 [revised]
PHST- 2010/10/25 00:00 [accepted]
PHST- 2010/12/21 06:00 [entrez]
PHST- 2010/12/21 06:00 [pubmed]
PHST- 2011/06/16 06:00 [medline]
PHST- 2012/01/07 00:00 [pmc-release]
AID - S1934-5909(10)00648-X [pii]
AID - 10.1016/j.stem.2010.11.026 [doi]
PST - ppublish
SO  - Cell Stem Cell. 2011 Jan 7;8(1):84-95. doi: 10.1016/j.stem.2010.11.026. Epub 2010 
      Dec 16.