PMID- 21213102
OWN - NLM
STAT- MEDLINE
DCOM- 20110629
LR  - 20220330
IS  - 1674-8018 (Electronic)
IS  - 1674-800X (Print)
IS  - 1674-800X (Linking)
VI  - 1
IP  - 12
DP  - 2010 Dec
TI  - Structural and functional insights into the TEAD-YAP complex in the Hippo 
      signaling pathway.
PG  - 1073-83
LID - 10.1007/s13238-010-0138-3 [doi]
AB  - The control of organ size growth is one of the most fundamental aspects of life. 
      In the past two decades, a highly conserved Hippo signaling pathway has been 
      identified as a key molecular mechanism for governing organ size regulation. In 
      the middle of this pathway is a kinase cascade that negatively regulates the 
      downstream component Yes-associated protein (YAP)/transcriptional coactivator 
      with PDZ-binding motif (TAZ)/Yorkie through phosphorylation. Phosphorylation of 
      YAP/TAZ/Yorkie promotes its cytoplasmic localization, leads to cell apoptosis and 
      restricts organ size overgrowth. When the Hippo pathway is inactivated, 
      YAP/TAZ/Yorkie translocates into the nucleus to bind to the transcription 
      enhancer factor (TEAD/TEF) family of transcriptional factors to promote cell 
      growth and proliferation. In this review, we will focus on the structural and 
      functional studies on the downstream transcription factor TEAD and its 
      coactivator YAP.
FAU - Chen, Liming
AU  - Chen L
AD  - Cancer and Developmental Cell Biology Division, Institute of Molecular and Cell 
      Biology, A*STAR (Agency for Science, Technology and Research), 61 Biopolis Drive, 
      Singapore 138673, Republic of Singapore.
FAU - Loh, Portia Gloria
AU  - Loh PG
FAU - Song, Haiwei
AU  - Song H
LA  - eng
PT  - Journal Article
DEP - 20110108
PL  - Germany
TA  - Protein Cell
JT  - Protein & cell
JID - 101532368
RN  - 0 (Drosophila Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (YAP-Signaling Proteins)
RN  - 0 (Yki protein, Drosophila)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (hpo protein, Drosophila)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Cell Proliferation
MH  - Drosophila/genetics/metabolism
MH  - Drosophila Proteins/genetics/*metabolism
MH  - Gene Expression Regulation, Developmental
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins/genetics/*metabolism
MH  - Mice
MH  - Nuclear Proteins/genetics/*metabolism
MH  - Organ Size/physiology
MH  - PDZ Domains
MH  - Phosphorylation
MH  - Protein Binding
MH  - Protein Serine-Threonine Kinases/genetics/*metabolism
MH  - Signal Transduction/*physiology
MH  - Trans-Activators/genetics/*metabolism
MH  - YAP-Signaling Proteins
PMC - PMC4728155
EDAT- 2011/01/08 06:00
MHDA- 2011/06/30 06:00
PMCR- 2010/12/01
CRDT- 2011/01/08 06:00
PHST- 2010/11/08 00:00 [received]
PHST- 2010/11/14 00:00 [accepted]
PHST- 2011/01/08 06:00 [entrez]
PHST- 2011/01/08 06:00 [pubmed]
PHST- 2011/06/30 06:00 [medline]
PHST- 2010/12/01 00:00 [pmc-release]
AID - 138 [pii]
AID - 10.1007/s13238-010-0138-3 [doi]
PST - ppublish
SO  - Protein Cell. 2010 Dec;1(12):1073-83. doi: 10.1007/s13238-010-0138-3. Epub 2011 
      Jan 8.