PMID- 21215705
OWN - NLM
STAT- MEDLINE
DCOM- 20110314
LR  - 20211020
IS  - 1878-3686 (Electronic)
IS  - 1535-6108 (Print)
IS  - 1535-6108 (Linking)
VI  - 19
IP  - 1
DP  - 2011 Jan 18
TI  - Basal cell carcinomas arise from hair follicle stem cells in Ptch1(+/-) mice.
PG  - 114-24
LID - 10.1016/j.ccr.2010.11.007 [doi]
AB  - Basal cell carcinomas (BCCs) are hedgehog-driven tumors that resemble follicular 
      and interfollicular epidermal basal keratinocytes and hence long have been 
      thought to arise from these cells. However, the actual cell of origin is unknown. 
      Using cell fate tracking of X-ray induced BCCs in Ptch1(+/-) mice, we found their 
      essentially exclusive origin to be keratin 15-expressing stem cells of the 
      follicular bulge. However, conditional loss of p53 not only enhanced BCC 
      carcinogenesis from the bulge but also produced BCCs from the interfollicular 
      epidermis, at least in part by enhancing Smo expression. This latter finding is 
      consistent with the lack of visible tumors on ears and tail, sites lacking Smo 
      expression, in Ptch1(+/-) mice.
CI  - Copyright A(c) 2011 Elsevier Inc. All rights reserved.
FAU - Wang, Grace Ying
AU  - Wang GY
AD  - Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, 
      Oakland, CA 94609, USA.
FAU - Wang, Joy
AU  - Wang J
FAU - Mancianti, Maria-Laura
AU  - Mancianti ML
FAU - Epstein, Ervin H Jr
AU  - Epstein EH Jr
LA  - eng
GR  - R01 CA115992/CA/NCI NIH HHS/United States
GR  - R01 CA115992-01A2/CA/NCI NIH HHS/United States
GR  - R01 CA115992-02/CA/NCI NIH HHS/United States
GR  - R01 CA115992-03/CA/NCI NIH HHS/United States
GR  - R01 CA115992-04/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20110106
PL  - United States
TA  - Cancer Cell
JT  - Cancer cell
JID - 101130617
RN  - 0 (Bacterial Proteins)
RN  - 0 (Ccnb1 protein, mouse)
RN  - 0 (Cyclin B1)
RN  - 0 (Keratin-14)
RN  - 0 (Keratin-15)
RN  - 0 (Krt14 protein, mouse)
RN  - 0 (Krt15 protein, mouse)
RN  - 0 (Luminescent Proteins)
RN  - 0 (Patched Receptors)
RN  - 0 (Patched-1 Receptor)
RN  - 0 (Ptch1 protein, mouse)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (Smo protein, mouse)
RN  - 0 (Smoothened Receptor)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - 0 (yellow fluorescent protein, Bacteria)
SB  - IM
CIN - Cancer Cell. 2011 Jan 18;19(1):5-6. PMID: 21251609
MH  - Animals
MH  - Bacterial Proteins/genetics
MH  - Carcinoma, Basal Cell/*etiology/metabolism/pathology
MH  - Cell Nucleus/metabolism
MH  - Cyclin B1/metabolism
MH  - Epidermis/pathology/radiation effects
MH  - Hair Follicle/metabolism/*pathology/radiation effects
MH  - Heterozygote
MH  - Keratin-14/genetics/metabolism
MH  - Keratin-15/genetics/metabolism
MH  - Keratinocytes/metabolism/pathology/radiation effects
MH  - Luminescent Proteins/genetics
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Mice, Transgenic
MH  - Patched Receptors
MH  - Patched-1 Receptor
MH  - Receptors, Cell Surface/*genetics
MH  - Receptors, G-Protein-Coupled/metabolism
MH  - Smoothened Receptor
MH  - Stem Cells/metabolism/*pathology/radiation effects
MH  - Tumor Suppressor Protein p53/genetics
MH  - X-Rays
PMC - PMC3061401
MID - NIHMS263302
EDAT- 2011/01/11 06:00
MHDA- 2011/03/15 06:00
PMCR- 2012/01/18
CRDT- 2011/01/11 06:00
PHST- 2010/06/25 00:00 [received]
PHST- 2010/09/08 00:00 [revised]
PHST- 2010/11/03 00:00 [accepted]
PHST- 2011/01/11 06:00 [entrez]
PHST- 2011/01/11 06:00 [pubmed]
PHST- 2011/03/15 06:00 [medline]
PHST- 2012/01/18 00:00 [pmc-release]
AID - S1535-6108(10)00472-1 [pii]
AID - 10.1016/j.ccr.2010.11.007 [doi]
PST - ppublish
SO  - Cancer Cell. 2011 Jan 18;19(1):114-24. doi: 10.1016/j.ccr.2010.11.007. Epub 2011 
      Jan 6.