PMID- 21238929
OWN - NLM
STAT- MEDLINE
DCOM- 20110216
LR  - 20220129
IS  - 1878-1551 (Electronic)
IS  - 1534-5807 (Print)
IS  - 1534-5807 (Linking)
VI  - 20
IP  - 1
DP  - 2011 Jan 18
TI  - Cooperative regulation of growth by Yorkie and Mad through bantam.
PG  - 109-22
LID - 10.1016/j.devcel.2010.12.002 [doi]
AB  - The Dpp and Fat-Hippo signaling pathways both regulate growth in Drosophila. Dpp 
      is a BMP family ligand and acts via a Smad family DNA-binding transcription 
      factor, Mad. Fat-Hippo signaling acts via a non-DNA-binding transcriptional 
      coactivator protein, Yorkie. Here, we show that these pathways are directly 
      interlinked. They act synergistically to promote growth, in part via regulation 
      of the microRNA gene bantam, and their ability to promote growth is mutually 
      dependent. Yorkie and Mad physically bind each other, and we identify a 410 bp 
      minimal enhancer of bantam that responds to Yorkie:Mad in vivo and in cultured 
      cells, and show that both Yorkie and Mad associate with this enhancer in vivo. 
      Our results indicate that in promoting the growth of Drosophila tissues, 
      Fat-Hippo and Dpp signaling contribute distinct subunits of a shared 
      transcriptional activation complex, Yorkie:Mad.
CI  - Copyright A(c) 2011 Elsevier Inc. All rights reserved.
FAU - Oh, Hyangyee
AU  - Oh H
AD  - Howard Hughes Medical Institute, Waksman Institute and Department of Molecular 
      Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA.
FAU - Irvine, Kenneth D
AU  - Irvine KD
LA  - eng
GR  - GM078620/GM/NIGMS NIH HHS/United States
GR  - 1F32GM079817/GM/NIGMS NIH HHS/United States
GR  - F32 GM079817/GM/NIGMS NIH HHS/United States
GR  - R01 GM078620-04/GM/NIGMS NIH HHS/United States
GR  - HHMI/Howard Hughes Medical Institute/United States
GR  - F32 GM079817-03/GM/NIGMS NIH HHS/United States
GR  - R01 GM078620/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Dev Cell
JT  - Developmental cell
JID - 101120028
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (MAD protein, Drosophila)
RN  - 0 (MicroRNAs)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 0 (YAP-Signaling Proteins)
RN  - 0 (Yki protein, Drosophila)
RN  - 0 (bantam microRNA, Drosophila)
SB  - IM
MH  - Animals
MH  - DNA-Binding Proteins/*metabolism
MH  - Drosophila Proteins/*metabolism
MH  - Drosophila melanogaster/cytology/genetics/*growth & development/*metabolism
MH  - Enhancer Elements, Genetic/genetics
MH  - Gene Expression Regulation, Developmental
MH  - MicroRNAs/genetics/*metabolism
MH  - Nuclear Proteins/*metabolism
MH  - Protein Binding
MH  - Trans-Activators/*metabolism
MH  - Transcription Factors/*metabolism
MH  - Wings, Animal/cytology/growth & development/metabolism
MH  - YAP-Signaling Proteins
PMC - PMC3033745
MID - NIHMS267068
EDAT- 2011/01/18 06:00
MHDA- 2011/02/17 06:00
PMCR- 2011/07/18
CRDT- 2011/01/18 06:00
PHST- 2010/05/08 00:00 [received]
PHST- 2010/11/01 00:00 [revised]
PHST- 2010/12/06 00:00 [accepted]
PHST- 2011/01/18 06:00 [entrez]
PHST- 2011/01/18 06:00 [pubmed]
PHST- 2011/02/17 06:00 [medline]
PHST- 2011/07/18 00:00 [pmc-release]
AID - S1534-5807(10)00583-6 [pii]
AID - 10.1016/j.devcel.2010.12.002 [doi]
PST - ppublish
SO  - Dev Cell. 2011 Jan 18;20(1):109-22. doi: 10.1016/j.devcel.2010.12.002.