PMID- 21252048
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20211020
IS  - 1522-1547 (Electronic)
IS  - 0193-1857 (Print)
IS  - 0193-1857 (Linking)
VI  - 300
IP  - 5
DP  - 2011 May
TI  - Intestinal myofibroblasts: targets for stem cell therapy.
PG  - G684-96
LID - 10.1152/ajpgi.00474.2010 [doi]
AB  - The subepithelial intestinal myofibroblast is an important cell orchestrating 
      many diverse functions in the intestine and is involved in growth and repair, 
      tumorigenesis, inflammation, and fibrosis. The myofibroblast is but one of 
      several alpha-smooth muscle actin-positive (alpha-SMA(+)) mesenchymal cells present 
      within the intestinal lamina propria, including vascular pericytes, bone 
      marrow-derived stem cells (mesenchymal stem cells or hematopoietic stem cells), 
      muscularis mucosae, and the lymphatic pericytes (colon) and organized smooth 
      muscle (small intestine) associated with the lymphatic lacteals. These other 
      mesenchymal cells perform many of the functions previously attributed to 
      subepithelial myofibroblasts. This review discusses the definition of a 
      myofibroblast and reconsiders whether the alpha-SMA(+) subepithelial cells in the 
      intestine are myofibroblasts or other types of mesenchymal cells, i.e., 
      pericytes. Current information about specific, or not so specific, molecular 
      markers of lamina propria mesenchymal cells is reviewed, as well as the origins 
      of intestinal myofibroblasts and pericytes in the intestinal lamina propria and 
      their replenishment after injury. Current concepts and research on stem cell 
      therapy for intestinal inflammation are summarized. Information about the stem 
      cell origin of intestinal stromal cells may inform future stem cell therapies to 
      treat human inflammatory bowel disease (IBD).
FAU - Mifflin, R C
AU  - Mifflin RC
AD  - Depts. of Internal Medicine, University of Texas Medical Branch, Galveston, USA.
FAU - Pinchuk, I V
AU  - Pinchuk IV
FAU - Saada, J I
AU  - Saada JI
FAU - Powell, D W
AU  - Powell DW
LA  - eng
GR  - CA-127229/CA/NCI NIH HHS/United States
GR  - DK-55783/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110120
PL  - United States
TA  - Am J Physiol Gastrointest Liver Physiol
JT  - American journal of physiology. Gastrointestinal and liver physiology
JID - 100901227
RN  - 0 (ACTA2 protein, human)
RN  - 0 (Actins)
SB  - IM
MH  - Actins/metabolism
MH  - Animals
MH  - Humans
MH  - Intestines/cytology
MH  - Myofibroblasts/*physiology
MH  - Pericytes/physiology
MH  - *Stem Cell Transplantation
MH  - Stromal Cells/physiology
PMC - PMC3094146
EDAT- 2011/01/22 06:00
MHDA- 2011/06/29 06:00
PMCR- 2012/05/01
CRDT- 2011/01/22 06:00
PHST- 2011/01/22 06:00 [entrez]
PHST- 2011/01/22 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
PHST- 2012/05/01 00:00 [pmc-release]
AID - ajpgi.00474.2010 [pii]
AID - GI-00474-2010 [pii]
AID - 10.1152/ajpgi.00474.2010 [doi]
PST - ppublish
SO  - Am J Physiol Gastrointest Liver Physiol. 2011 May;300(5):G684-96. doi: 
      10.1152/ajpgi.00474.2010. Epub 2011 Jan 20.