PMID- 21252997
OWN - NLM
STAT- MEDLINE
DCOM- 20110216
LR  - 20220318
IS  - 1471-0080 (Electronic)
IS  - 1471-0072 (Linking)
VI  - 12
IP  - 2
DP  - 2011 Feb
TI  - Dedifferentiation, transdifferentiation and reprogramming: three routes to 
      regeneration.
PG  - 79-89
LID - 10.1038/nrm3043 [doi]
AB  - The ultimate goal of regenerative medicine is to replace lost or damaged cells. 
      This can potentially be accomplished using the processes of dedifferentiation, 
      transdifferentiation or reprogramming. Recent advances have shown that the 
      addition of a group of genes can not only restore pluripotency in a fully 
      differentiated cell state (reprogramming) but can also induce the cell to 
      proliferate (dedifferentiation) or even switch to another cell type 
      (transdifferentiation). Current research aims to understand how these processes 
      work and to eventually harness them for use in regenerative medicine.
FAU - Jopling, Chris
AU  - Jopling C
AD  - Center of Regenerative Medicine in Barcelona, Dr. Aiguader, 88, 08003 Barcelona, 
      Spain.
FAU - Boue, Stephanie
AU  - Boue S
FAU - Izpisua Belmonte, Juan Carlos
AU  - Izpisua Belmonte JC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Nat Rev Mol Cell Biol
JT  - Nature reviews. Molecular cell biology
JID - 100962782
SB  - IM
MH  - Animals
MH  - Cell Cycle
MH  - *Cell Dedifferentiation
MH  - *Cell Transdifferentiation
MH  - *Cellular Reprogramming
MH  - Humans
MH  - Induced Pluripotent Stem Cells/cytology
MH  - Regenerative Medicine
EDAT- 2011/01/22 06:00
MHDA- 2011/02/17 06:00
CRDT- 2011/01/22 06:00
PHST- 2011/01/22 06:00 [entrez]
PHST- 2011/01/22 06:00 [pubmed]
PHST- 2011/02/17 06:00 [medline]
AID - nrm3043 [pii]
AID - 10.1038/nrm3043 [doi]
PST - ppublish
SO  - Nat Rev Mol Cell Biol. 2011 Feb;12(2):79-89. doi: 10.1038/nrm3043.